©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 16, 2018; 6(1): 1-5
Published online Jan 16, 2018. doi: 10.12998/wjcc.v6.i1.1
Published online Jan 16, 2018. doi: 10.12998/wjcc.v6.i1.1
Hereditary diffuse gastric cancer: One family’s story
Haley M Zylberberg, Steven Rubin, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, United States
Keith Sultan, Division of Gastroenterology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY 11030, United States
Steven Rubin, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Merrick, NY 11566, United States
Author contributions: Zylberberg HM, Sultan K and Rubin S designed the report; Zylberberg HM and Rubin S collected the patient’s clinical data; Zylberberg HM, Sultan K and Rubin S analyzed the data, drafted and edited the manuscript; all authors approve the final manuscript submitted and they approve the authorship list.
Informed consent statement: Informed consent was obtained from the patient by the article guarantor.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest and nothing to declare.
Correspondence to: Keith Sultan, MD, Assistant Professor, Division of Gastroenterology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Dr., Manhasset, NY 11030, United States. ksultan@northwell.edu
Telephone: +1-516-3873990
Received: November 9, 2017
Peer-review started: November 9, 2017
First decision: November 30, 2017
Revised: December 8, 2017
Accepted: December 13, 2017
Article in press: December 13, 2017
Published online: January 16, 2018
Processing time: 64 Days and 0.7 Hours
Peer-review started: November 9, 2017
First decision: November 30, 2017
Revised: December 8, 2017
Accepted: December 13, 2017
Article in press: December 13, 2017
Published online: January 16, 2018
Processing time: 64 Days and 0.7 Hours
Core Tip
Core tip: Individuals who carry the CDH1 gene mutation are at very high risk of acquiring hereditary diffuse gastric cancer, a cancer with a high mortality if not detected early. The clinical findings we describe in this case may aid medical practitioners in the assessment and testing of patients with a family history of gastric cancer and raise awareness about the importance of genetic testing for this condition.