Systematic Reviews
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2015; 3(9): 807-822
Published online Sep 16, 2015. doi: 10.12998/wjcc.v3.i9.807
Role of genetic polymorphisms in hepatitis C virus chronic infection
Nicola Coppola, Mariantonietta Pisaturo, Caterina Sagnelli, Lorenzo Onorato, Evangelista Sagnelli
Nicola Coppola, Mariantonietta Pisaturo, Lorenzo Onorato, Evangelista Sagnelli, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, 80131 Naples, Italy
Caterina Sagnelli, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, 80131 Naples, Italy
Author contributions: All the authors equally contributed to this work.
Conflict-of-interest statement: All the authors of the manuscript declare that they have no conflict of interest in connection with this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Nicola Coppola, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via: L. Armanni 5, 80131 Naples, Italy. nicola.coppola@unina2.it
Telephone: +39-81-5666719 Fax: +39-81-5666013
Received: July 27, 2014
Peer-review started: July 27, 2014
First decision: November 27, 2014
Revised: December 9, 2014
Accepted: June 4, 2015
Article in press: June 8, 2015
Published online: September 16, 2015
Processing time: 415 Days and 14.9 Hours
Core Tip

Core tip: Some single nucleotide polymorphisms have been associated with the clinical presentation and/or response to antiviral treatment in subjects with chronic hepatitis C (CHC). In this review article the effect of old and new host genetics factors [interleukin 28B, inosine triphosphate pyrophosphatase, patatin-like phospholipase domain, cannabinoid receptor type 2 (CB2-63), vitamin D associated polymorphisms, etc.] on the outcome of CHC and the response to antiviral treatment will be presented, analyzed and discussed, to provide some guidance for individualized therapies in clinical practice.