©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2015; 3(4): 345-352
Published online Apr 16, 2015. doi: 10.12998/wjcc.v3.i4.345
Published online Apr 16, 2015. doi: 10.12998/wjcc.v3.i4.345
Atherosclerosis and the role of immune cells
Fulya Ilhan, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey
Sevgi Tas Kalkanli, Department of Immunology, Faculty of Medicine, University of Dicle, 21280 Diyarbakir, Turkey
Author contributions: İlhan F and Kalkanli ST contributed equally to writing the manuscript; both authors revised the article and approved the final version.
Conflict-of-interest: There is no conflict of interest.
Correspondence to: Fulya Ilhan, MD, PhD, Professor, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey. fulhan23@yahoo.com
Telephone: +90-424-2122960 Fax: +90-424-2379138
Received: May 13, 2014
Peer-review started: May 13, 2014
First decision: June 6, 2014
Revised: December 1, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: April 16, 2015
Processing time: 334 Days and 22.9 Hours
Peer-review started: May 13, 2014
First decision: June 6, 2014
Revised: December 1, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: April 16, 2015
Processing time: 334 Days and 22.9 Hours
Core Tip
Core tip: Activated endothelium to adhere to the endothelium and move into the intima with the expression of adhesion molecules appears to be an early event in atherosclerosis, which allows mononuclear leukocytes such as monocytes and T-cells. This inflammatory mechanism must be explained before determining a new therapy.