Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2015; 3(2): 89-101
Published online Feb 16, 2015. doi: 10.12998/wjcc.v3.i2.89
State-of-the-Art management of knee osteoarthritis
Kenton H Fibel, Howard J Hillstrom, Brian C Halpern
Kenton H Fibel, Brian C Halpern, Department of Medicine, Primary Care Sports Medicine, Hospital for Special Surgery, New York, NY 10021, United States
Howard J Hillstrom, Leon Root Motion Analysis Laboratory, Department of Rehabilitation, Hospital for Special Surgery, New York, NY 10021, United States
Author contributions: Fibel KH, Hillstrom HJ and Halpern BC solely contributed to this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Brian C Halpern, MD, Department of Medicine, Primary Care Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States. halpernb@hss.edu
Telephone: +1-212-6061329 Fax: +1-212-5706147
Received: June 30, 2014
Peer-review started: June 30, 2014
First decision: September 16, 2014
Revised: September 29, 2014
Accepted: October 28, 2014
Article in press: October 29, 2014
Published online: February 16, 2015
Processing time: 220 Days and 6.5 Hours
Core Tip

Core tip: The management of knee osteoarthritis is of growing importance in the world and especially in the United States where an aging population and increasing trends in obesity are increasing the prevalence of this disease. Treatment has traditionally focused on symptom control, however, more recently there has been a greater emphasis placed on developing new modalities that aim to slow disease progression or even reverse the process. This review aims to examine the available literature on such modalities ranging from patient education and weight loss to disease-modifying osteoarthritis drugs to platelet-rich plasma, stem cells, and other emerging injectables.