Rondanelli M, Giacosa A, Faliva MA, Perna S, Allieri F, Castellazzi AM. Review on microbiota and effectiveness of probiotics use in older. World J Clin Cases 2015; 3(2): 156-162 [PMID: 25685762 DOI: 10.12998/wjcc.v3.i2.156]
Corresponding Author of This Article
Mariangela Rondanelli, Professor, Department of Public Health, Experimental and Forensic Medicine, School of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia 27100, Italy. mariangela.rondanelli@unipv.it
Research Domain of This Article
Nutrition & Dietetics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 16, 2015; 3(2): 156-162 Published online Feb 16, 2015. doi: 10.12998/wjcc.v3.i2.156
Review on microbiota and effectiveness of probiotics use in older
Mariangela Rondanelli, Attilio Giacosa, Milena Anna Faliva, Simone Perna, Francesca Allieri, Anna Maria Castellazzi
Mariangela Rondanelli, Milena Anna Faliva, Simone Perna, Francesca Allieri, Department of Applied Health Sciences, Azienda di Servizi alla Persona di Pavia, University of Pavia, 27100 Pavia, Italy
Mariangela Rondanelli, Department of Public Health, Experimental and Forensic Medicine, School of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia 27100, Italy
Attilio Giacosa, Department of Gastroenterology, Policlinico di Monza, 20900 Monza, Italy
Anna Maria Castellazzi, Department of Clinical-Surgical, Diagnostic and Pediatrics Sciences, University of Pavia, 27100 Pavia, Italy
Author contributions: Rondanelli M, Giacosa A and Castellazzi AM designed research; Faliva MA, Perna S and Allieri F performed research; Rondanelli M, Giacosa A and Castellazzi AM analyzed data; Rondanelli M wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mariangela Rondanelli, Professor, Department of Public Health, Experimental and Forensic Medicine, School of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Pavia 27100, Italy. mariangela.rondanelli@unipv.it
Telephone: +39-382-381749 Fax: +39-382-381218
Received: July 27, 2014 Peer-review started: July 28, 2014 First decision: September 16, 2014 Revised: October 9, 2014 Accepted: October 28, 2014 Article in press: October 29, 2014 Published online: February 16, 2015 Processing time: 192 Days and 23.6 Hours
Core Tip
Core tip: The intestinal microbiota of elderly manifested a reduction in the diversity, characterized by a large interindividual variability, with lower numbers of Firmicutes, Bifidobacteria, Clostridium cluster XIV, Faecalibacterium Prausnitzii, Blautia coccoides-Eubacterium rectal and higher in Enterobacteriaceae and Bacteroidetes. These derangements may not necessarily aging-correlated, but they can be consequent to the decline of general state of health, malnutrition and increased use of drugs. As regards probiotics, the main double-blind studies in the elderly have shown that use is safe and could represent an interesting support to reduced frequency and/or duration of antibiotic-associated diarrhea, other than to help for constipation.
