Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Oct 26, 2026; 14(28): 127546
Published online Oct 26, 2026. doi: 10.12998/wjcc.127546
Published online Oct 26, 2026. doi: 10.12998/wjcc.127546
Esophageal stricture due to amyloidosis in plasma cell dyscrasia: A case report and review of literature
Sanjeev Sachdeva, Nikhil Sirohi, Koushik Mandal, Dhruv Bansal, Venkatesh Vaithiyam, Ashok Dalal, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India
Venkatesh Vaithiyam, Department of Gastroenterology, Apollo Speciality Hospital, Madurai 625020, Tamil Nādu, India
Surbhi Goyal, Puja Sakhuja, Department of Pathology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India
Author contributions: Sirohi N and Vaithiyam V wrote the original draft; Mandal K, Bansal D, and Sachdeva S contributed to patient care, conceptualization, writing, reviewing, and editing; Sirohi N, Dalal A, and Vaithiyam V participated in drafting the manuscript; Sakhuja P and Goyal S performed the pathological review of the patient; Sachdeva S performed the final review of the manuscript; and all authors have read and approved the final version of the manuscript.
AI contribution statement: ChatGPT, Grammarly, and Paperpal were also used for language editing, grammar correction, and sentence refinement. All AI-assisted content was reviewed and verified by the authors, who take full responsibility for the final manuscript and figures.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Venkatesh Vaithiyam, DM, MD, Consultant, Department of Gastroen
Received: September 1, 2026
Revised: October 4, 2026
Accepted: October 20, 2026
Published online: October 26, 2026
Processing time: 52 Days and 17.2 Hours
Revised: October 4, 2026
Accepted: October 20, 2026
Published online: October 26, 2026
Processing time: 52 Days and 17.2 Hours
Core Tip
Core Tip: Esophageal involvement in systemic amyloidosis is rare and presents in variable ways. We report a 65-year-old woman with progressive dysphagia, weight loss, and an upper esophageal stricture. Biopsy demonstrated Congo red-positive amyloid with lambda light-chain restriction, and bone marrow examination revealed approximately 50% lambda-restricted plasma cells, establishing an underlying plasma-cell dyscrasia. Although fat-pad and rectal biopsies were negative, a direct esophageal biopsy confirmed amyloid deposition at the site of disease. Endoscopic balloon dilation resulted in complete resolution of dysphagia, and daratumumab, bortezomib, cyclophosphamide, and dexamethasone therapy was initiated for disease modification.