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World J Clin Cases. Sep 26, 2026; 14(27): 126756
Published online Sep 26, 2026. doi: 10.12998/wjcc.126756
Published online Sep 26, 2026. doi: 10.12998/wjcc.126756
Priapism as a rare adverse effect of levomepromazine: A case report
Mohammed Taloubi, Department of Anesthesiology and Critical Care, Mohammed VI Uni
Ait Sayad Lamya, Ghizlane El Aidouni, Emergency Unit of the Specialized Hospital, Mohammed VI University Hospital Center, Oujda 60010, Morocco
Author contributions: Taloubi M contributed to the conceptualization of the case report, data collection, literature review, manuscript drafting, and critical revision of the manuscript; Ait Sayad L contributed to data collection, clinical management, literature review, and critical revision of the manuscript; El Aidouni G contributed to clinical management, supervision, and critical revision of the manuscript; and all authors read and approved the final version of the manuscript.
AI contribution statement: ChatGPT (OpenAI) was used solely as an assistive tool for language refinement, grammatical correction, and improvement of the clarity and organization of selected sections of the manuscript. It was not used to independently generate the scientific content, clinical data, interpretation, or conclusions of the manuscript. All AI-assisted content was critically reviewed, verified, and revised by the authors, who take full responsibility for the accuracy, originality, integrity, and scientific content of the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of the details of this case report.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Mohammed Taloubi, MD, Department of Anesthesiology and Critical Care, Mohammed VI University Hospital Center, Rue El Aounia Lot El Ouiam Rue D1 NR 12, Oujda 60010, Morocco. taloubi.mohammed.16@gmail.com
Received: August 21, 2026
Revised: September 29, 2026
Accepted: October 12, 2026
Published online: September 26, 2026
Processing time: 62 Days and 9.7 Hours
Revised: September 29, 2026
Accepted: October 12, 2026
Published online: September 26, 2026
Processing time: 62 Days and 9.7 Hours
Core Tip
Core Tip: Levomepromazine-associated priapism is rarely reported despite the drug’s substantial α1-adrenergic antagonistic activity. This case is notable for the development of severe ischemic priapism only 48 hours after initiation of levomepromazine monotherapy at a therapeutic dose, with complete absence of penile pain despite profound cavernosal hypoxia and acidosis. Failure of intracavernosal phenylephrine ultimately required surgical shunting. This observation emphasizes that absence of pain does not exclude severe ischemia and that persistent erections during antipsychotic therapy require prompt evaluation and treatment to prevent irreversible cavernosal injury.