Zhao TJ, Chen SL, Zhou YL, Jin ZJ, Huang GS. Multicomponent metaplastic breast cancer with four histological components: A case report. World J Clin Cases 2026; 14(27): 126027 [DOI: 10.12998/wjcc.126027]
Corresponding Author of This Article
Gao-Shi Huang, PhD, Department of General Surgery, The First People’s Hospital of Wuyi County, No. 2 Nanmen Street, Wuyi County, Jinhua 321200, Zhejiang Province, China. 3290029855@qq.com
Research Domain of This Article
Surgery
Article-Type of This Article
case-report
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Zhao TJ, Chen SL, Zhou YL, Jin ZJ, Huang GS. Multicomponent metaplastic breast cancer with four histological components: A case report. World J Clin Cases 2026; 14(27): 126027 [DOI: 10.12998/wjcc.126027]
Ting-Jun Zhao, Shi-Lei Chen, Yun-Long Zhou, Zheng-Jia Jin, Gao-Shi Huang, Department of General Surgery, The First People’s Hospital of Wuyi County, Jinhua 321200, Zhejiang Province, China
Co-first authors: Ting-Jun Zhao and Shi-Lei Chen.
Author contributions: Zhao TJ and Chen SL contributed to data curation, writing - original draft; Zhou YL and Jin ZJ contributed to investigation; Zhou YL, Jin ZJ, and Huang GS contributed to writing - review & editing; Huang GS contributed to conceptualization and supervision.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Gao-Shi Huang, PhD, Department of General Surgery, The First People’s Hospital of Wuyi County, No. 2 Nanmen Street, Wuyi County, Jinhua 321200, Zhejiang Province, China. 3290029855@qq.com
Received: July 23, 2026 Revised: August 31, 2026 Accepted: October 9, 2026 Published online: September 26, 2026 Processing time: 82 Days and 23 Hours
Core Tip
Core Tip: Metaplastic breast cancer (MMBC) is a rare breast malignancy with poor prognosis and a lack of standardized treatment strategies. We report a rare case of MMBC with three invasive components plus associated ductal carcinoma in situ components, a presentation that is seldom encountered in clinical practice. The tumor exhibits a triple-negative phenotype, a high Ki-67 proliferation index, and TP53 and AKT1 gene mutations. The patient completed 8 cycles of sequential Pirarubicin plus cyclophosphamide followed by docetaxel plus cisplatin adjuvant chemotherapy, with manageable grade 2-3 adverse reactions. No local recurrence or distant metastasis was observed during the 20-month follow-up period. This case provides clinical evidence for diagnosis, individualized therapy, and prognostic evaluation of multicomponent MMBC.
