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World J Clin Cases. Sep 6, 2026; 14(25): 124208
Published online Sep 6, 2026. doi: 10.12998/wjcc.124208
Published online Sep 6, 2026. doi: 10.12998/wjcc.124208
Concurrent sarcoidosis and hemophagocytic lymphohistiocytosis: A case report
Maryam Almasaabi, Sarah Masood, Ghassan Elsayed, Department of Gastroenterology, Mediclinic Middle East Hospital, Abu Dhabi W67, United Arab Emirates
Co-first authors: Maryam Almasaabi and Sarah Masood.
Author contributions: Almasaabi M, Masood S, and Elsayed G contributed to study conceptualization, data collection, manuscript writing and revision, and data interpretation; Elsayed G contributed to radiological analysis and endoscopic procedures, project supervision, and critical manuscript review, and provided final approval of the manuscript; Almasaabi M and Masood S contributed equally to this work and share co-first authorship, as both were equally involved in the study design, data acquisition, data analysis, and primary drafting of the manuscript; and all authors have read and approved the final version of the manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools for language refinement. The authors were responsible and agree to be accountable for all scientific content.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Maryam Almasaabi, MBBS, Research Fellow, Department of Gas
Received: June 9, 2026
Revised: August 5, 2026
Accepted: August 28, 2026
Published online: September 6, 2026
Processing time: 86 Days and 13.5 Hours
Revised: August 5, 2026
Accepted: August 28, 2026
Published online: September 6, 2026
Processing time: 86 Days and 13.5 Hours
Core Tip
Core Tip: This case emphasizes the importance of considering sarcoidosis in adults presenting with unexplained hemophagocytic lymphohistiocytosis (HLH) after exclusion of infectious and malignant causes. Early use of the HScore facilitated prompt diagnosis and treatment initiation. Notably, the patient showed improvement with corticosteroid therapy alone, supporting a stepwise, individualized treatment approach in clinically stable sarcoidosis-associated HLH.