Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Aug 26, 2026; 14(24): 122937
Published online Aug 26, 2026. doi: 10.12998/wjcc.122937
Published online Aug 26, 2026. doi: 10.12998/wjcc.122937
Oxidative stress and inflammation in breast cancer: Mechanistic interactions and clinical implications
Şeyma Tutar, Yusuf Tutar, Division of Medicinal Biochemistry, Department of Basic Medical Sciences, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53020, Türkiye
Kezban Uçar Çifçi, Division of Basic Sciences and Health, Hemp Research Institute, Yozgat Bozok University, Yozgat 66900, Türkiye
Co-first authors: Şeyma Tutar and Kezban Uçar Çifçi.
Author contributions: Tutar Ş and Uçar Çifçi K contributed equally to this work; Tutar Y and Uçar ÇK conceptualized and designed the study, created the artwork, supervised, and made critical revisions; conducted the literature review; and Tutar Y drafted the original manuscript; all authors prepared the draft and approved the submitted version.
AI contribution statement: The authors used [ChatGPT-5.5] to improve the spelling and clarity of this manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior authors or other coauthors who contributed their efforts in this manuscript.
Corresponding author: Yusuf Tutar, Chairman, Dean, Tenured Professor, Division of Medicinal Biochemistry, Department of Basic Medical Sciences, Faculty of Medicine, Recep Tayyip Erdogan University, Islampaşa, Rize 53020, Türkiye. yusuf.tutar@erdogan.edu.tr
Received: May 11, 2026
Revised: June 18, 2026
Accepted: July 28, 2026
Published online: August 26, 2026
Processing time: 110 Days and 0.7 Hours
Revised: June 18, 2026
Accepted: July 28, 2026
Published online: August 26, 2026
Processing time: 110 Days and 0.7 Hours
Core Tip
Core Tip: This review integrates contemporary findings regarding the bidirectional interaction between oxidative stress and inflammation in breast cancer, emphasizing common signaling pathways that facilitate tumor initiation, development, and treatment resistance. This work examines how reactive oxygen species alter the tumor microenvironment, drive genetic instability, and sustain inflammation, while inflammatory mediators exacerbate oxidative damage. Furthermore, it assesses novel biomarkers and tailored therapies that leverage this interaction, providing insights into individualized therapeutic approaches and prospective tactics to improve treatment efficacy and address resistance.