Umbilical cord mesenchymal stem cells in diabetes mellitus

doi:10.12998/wjcc.121196

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Aug 16, 2026; 14(23): 121196
Published online Aug 16, 2026. doi: 10.12998/wjcc.121196

Umbilical cord mesenchymal stem cells in diabetes mellitus

Gumpeny R Sridhar, Suresh Anne, Lakshmi Gumpeny, Sanjana S N Narasimhadevara

Gumpeny R Sridhar, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, Visakhapatnam 530002, India

Suresh Anne, Department of Allergy and Immunology, Asthma, Allergy and Immunology Center, Flint, MI 48507, United States

Lakshmi Gumpeny, Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, India

Sanjana S N Narasimhadevara, Department of Endocrinology, Harbor-UCLA Medical Center, West Carson, CA 90745, United States

Author contributions: Sridhar GR, Anne S, Gumpeny L, and Narasimhadevara SSN contributed equally to the design of the manuscript, literature search and writing of the final version; and all authors thoroughly reviewed and endorsed the final manuscript.

AI contribution statement: Generative AI was not used in preparing the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Gumpeny R Sridhar, MD, DM, FACE, FRCP, Chief, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, India. sridharvizag@gmail.com

Received: March 18, 2026
Revised: July 2, 2026
Accepted: July 6, 2026
Published online: August 16, 2026
Processing time: 147 Days and 9.2 Hours

Core Tip

Core Tip: Umbilical cord mesenchymal stem cells have the potential to modify the course of diabetes mellitus, eventually leading to its possible cure. They regulate immune destruction of pancreatic β cells and can also regenerate them. Animal studies showed their effectiveness. Early human reports showed positive results. Larger long term human randomized clinical trials are needed to bring prospect to practice.