Relationship between inflammation, depression, and immune surveillance in oral cancer

doi:10.12998/wjcc.v14.i19.122106

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jul 6, 2026; 14(19): 122106
Published online Jul 6, 2026. doi: 10.12998/wjcc.v14.i19.122106

Relationship between inflammation, depression, and immune surveillance in oral cancer

Tabiha Khan, Shilpi Srivastava, Sivan Sathish

Sivan Sathish, Shilpi Srivastava, Tabiha Khan, Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad 244001, Uttar Pradesh, India

Author contributions: Sathish S conceptualized and designed the review, developed the overall framework, conducted the literature search, coordinated and performed manuscript writing, and prepared the figures and tables; Srivastava S contributed to literature evaluation and assisted in manuscript drafting; Khan T contributed to clinical interpretation and provided critical clinical insights for the manuscript.

AI contribution statement: No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions.

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

Corresponding author: Sivan Sathish, Head, Professor, Department of Oral Medicine and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Delhi Road, Moradabad 244001, Uttar Pradesh, India. drsivan.dental@tmu.ac.in

Received: April 10, 2026
Revised: May 6, 2026
Accepted: May 21, 2026
Published online: July 6, 2026
Processing time: 84 Days and 0.3 Hours

Core Tip

Core Tip: Inflammation, depression, and immune surveillance constitute a biologically integrated axis in oral cancer. Chronic inflammatory activation and depression-associated neuroendocrine dysregulation impair antitumor immune responses, leading to reduced immune surveillance, tumor progression, and immune evasion. Recognition of this integrated axis provides a mechanistic framework for disease progression and supports the development of improved prognostic models and integrative therapeutic strategies.