Mishra A, Shukla M, Khan MA, Pal A, Kanchan A. Association of lower urinary tract symptoms with restless leg syndrome and impaired somnolence pattern in middle aged and elderly men. World J Clin Cases 2026; 14(19): 120379 [DOI: 10.12998/wjcc.v14.i19.120379]
Corresponding Author of This Article
Amit Mishra, Associate Professor, FACS, Department of Urology, All India Institute of Medical Sciences (AIIMS), Munshiganj, Dalmau Road, Raebareli 229405, Uttar Pradesh, India. amit.mishra.uro@gmail.com
Research Domain of This Article
Urology & Nephrology
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research-article
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Mishra A, Shukla M, Khan MA, Pal A, Kanchan A. Association of lower urinary tract symptoms with restless leg syndrome and impaired somnolence pattern in middle aged and elderly men. World J Clin Cases 2026; 14(19): 120379 [DOI: 10.12998/wjcc.v14.i19.120379]
Association of lower urinary tract symptoms with restless leg syndrome and impaired somnolence pattern in middle aged and elderly men
Amit Mishra, Mukesh Shukla, Mohd Atif Khan, Arghya Pal, Arvind Kanchan
Amit Mishra, Mohd Atif Khan, Department of Urology, All India Institute of Medical Sciences (AIIMS), Raebareli 229405, Uttar Pradesh, India
Mukesh Shukla, Department of Community Medicine, All India Institute of Medical Sciences (AIIMS), Raebareli 229405, Uttar Pradesh, India
Arghya Pal, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Raebareli 229405, Uttar Pradesh, India
Arvind Kanchan, Department of Physiology, All India Institute of Medical Sciences (AIIMS), Raebareli 229405, Uttar Pradesh, India
Author contributions: Mishra A, Shukla M, and Pal A conceptualized and designed the research; Khan AM and Kanchan A enrolled, screened patients and acquired clinical data; Mishra A and Shukla M performed data analysis; Mishra A, Shukla M, and Khan MA wrote the paper. All the authors have read and approved the final manuscript.
AI contribution statement: The authors declare that ChatGPT was used only for paraphrasing and grammar check. No portion or entirety of the main manuscript was generated by AI. ChatGpt was used only for language polishing at specific points in the manuscript. No translation was done. Data analysis and writing of ideas/concepts was done by the authors only. No AI tool was used in the design of the study or interpretation of results. No images in the manuscript are generated by AI to the nest of the authors knowledge.
Institutional review board statement: This was obtained from the Institutional Ethics Committee of the All India Institute of Medical Sciences, Raebareli, Uttar Pradesh before the commencement of the study, No. 2023-9-IMP-5.
Informed consent statement: Informed written consent was obtained from the patients for study participation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data will be freely shared based on demand by the corresponding author.
Corresponding author: Amit Mishra, Associate Professor, FACS, Department of Urology, All India Institute of Medical Sciences (AIIMS), Munshiganj, Dalmau Road, Raebareli 229405, Uttar Pradesh, India. amit.mishra.uro@gmail.com
Received: February 26, 2026 Revised: March 20, 2026 Accepted: May 29, 2026 Published online: July 6, 2026 Processing time: 126 Days and 23.2 Hours
Core Tip
Core Tip: This study identifies a high prevalence (42.9%) of restless legs syndrome (RLS) among middle-aged and elderly men with lower urinary tract symptoms (LUTS), an area that remains relatively underexplored in urology. A significant association was observed between RLS and greater LUTS severity, particularly obstructive symptoms and nocturia. Despite comparable global sleep quality scores, patients with RLS demonstrated greater functional sleep impairment, reflected by increased sleep medication use and daytime dysfunction. These findings reveal a clinically meaningful interaction between LUTS and RLS, underscoring the importance of routine RLS screening in men with LUTS to enable more comprehensive, multidisciplinary management strategies.to enable more comprehensive and outcome-oriented management.
