Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Jun 16, 2026; 14(17): 120718
Published online Jun 16, 2026. doi: 10.12998/wjcc.v14.i17.120718
Published online Jun 16, 2026. doi: 10.12998/wjcc.v14.i17.120718
Pulmonary tuberculosis and nutritional vulnerability during anti-tumor necrosis factor therapy for inflammatory bowel disease: Two case reports
Merve Guney-Coskun, Department of Nutrition and Dietetics, Istanbul Medipol University, School of Health Sciences, Istanbul 34810, Beykoz, Türkiye
Metin Basaranoglu, Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, Istanbul 34093, Türkiye
Author contributions: Guney-Coskun M and Basaranoglu M contributed to manuscript writing and editing; Guney-Coskun M contributed to nutrient intake analysis; Basaranoglu M contributed to conceptualization and supervision; and all authors have read and approved the final manuscript.
AI contribution statement: AI-based language tools were used only for language editing and writing assistance to improve clarity and readability. All scientific content, clinical interpretation, case data, and conclusions were developed, reviewed, and approved entirely by the authors. No AI-generated images or data were used in this manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Merve Guney-Coskun, PhD, Lecturer, Department of Nutrition and Dietetics, Istanbul Medipol University, School of Health Sciences, Kavacık, Göztepe Mah, Atatürk Cd. No. 40, Istanbul 34810, Beykoz, Türkiye. merve.guney@medipol.edu.tr
Received: March 9, 2026
Revised: April 19, 2026
Accepted: May 7, 2026
Published online: June 16, 2026
Processing time: 88 Days and 17.2 Hours
Revised: April 19, 2026
Accepted: May 7, 2026
Published online: June 16, 2026
Processing time: 88 Days and 17.2 Hours
Core Tip
Core Tip: Standard latent tuberculosis (TB) infection screening before anti-tumor necrosis factor therapy does not fully protect against active TB in patients with inflammatory bowel disease (IBD). This report is the first to systematically document both nutritional deficiency and crowded dormitory exposure as concurrent, potentially modifiable risk factors in this setting. Clinicians managing IBD with biologic therapy should integrate routine nutritional assessment and environmental risk evaluation into their preventive approach, particularly for young patients in communal living settings. These findings support expanding TB prevention beyond serology to a multifactorial clinical framework.