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World J Clin Cases. Jun 6, 2026; 14(16): 120945
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.120945
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.120945
Serum vitamin D level and its association with anti-seizure medications in children with seizure disorder
Partha Sarathi Sahoo, Debi Prasad Jena, Pravakar Mishra, Department of Pediatrics, SCB Medical College, Cuttack 753007, Odisha, India
Pratima Kumari Sahu, Department of Biochemistry, SCB Medical College, Cuttack 753007, Odisha, India
Rashmi Ranjan Das, Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India
Co-first authors: Partha Sarathi Sahoo and Rashmi Ranjan Das.
Author contributions: Sahoo PS, Jena DP, Sahu PK, and Mishar P contributed to material preparation, and data acquisition; Sahoo PS, Jena DP, and Das RR contributed to data analysis; Sahoo PS, Mishra P, Das RR, and Sahu PK contributed to conceptualization and design; and all authors contributed to writing draft and writing revision and approved to submit the final version.
Institutional review board statement: The study was reviewed and approved by the Institute Ethics Committee, SCB Medical College & Hospital, Cuttack (Approval No. 1547; Dated: 23 November 2023).
Clinical trial registration statement: In India, the registration of a prospective (non-intervention) study is not mandatory. So, this study was not registered.
Informed consent statement: All study participants, or their legal guardians, provided written consent prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: There is no additional data available.
Corresponding author: Rashmi Ranjan Das, MD, FCCP, Professor, Department of Pediatrics, All India Institute of Medical Sciences, OPD Block, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. ped_rashmi@aiimsbhubaneswar.edu.in
Received: March 13, 2026
Revised: April 18, 2026
Accepted: May 6, 2026
Published online: June 6, 2026
Processing time: 71 Days and 6.9 Hours
Revised: April 18, 2026
Accepted: May 6, 2026
Published online: June 6, 2026
Processing time: 71 Days and 6.9 Hours
Core Tip
Core Tip: In this prospective longitudinal study of 150 children with epilepsy, vitamin D insufficiency was highly prevalent, affecting over 80% of participants. Although serum vitamin D levels showed a declining trend during follow-up, the change was not statistically significant, and no independent association with seizure control was observed. These findings suggest that while hypovitaminosis D is common in this population, its direct impact on seizure outcomes remains uncertain and warrants further controlled studies.