Gavkare AM, Nanaware NL, Darade R, Dhotre SV, Mumbre SS, Nagoba BS. Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases. World J Clin Cases 2026; 14(16): 119831 [DOI: 10.12998/wjcc.v14.i16.119831]
Corresponding Author of This Article
Basavraj S Nagoba, Assistant Dean, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. basavraj.nagoba@mimsr.edu.in
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases
Basavraj S Nagoba, Sachin S Mumbre, Shree V Dhotre, Rajesh Darade, Neeta L Nanaware, Ajay M Gavkare
Ajay M Gavkare, Department of Physiology, Government Medical College, Buldhana 443001, Maharashtra, India
Neeta L Nanaware, Department of Physiology, Vilasrao Deshmukh Government Medical College, Latur 413512, Maharashtra, India
Rajesh Darade, Department of Obstetrics and Gyanecology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Mahārāshtra, India
Shree V Dhotre, Department of Microbiology, Ashwini Rural Medical College, Hospital and Research Centre, Solapur 413006, Maharashtra, India
Sachin S Mumbre, Department of Community Medicine, Ashwini Rural Medical College, Solapur 413006, India
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India
Co-first authors: Ajay M Gavkare and Neeta L Nanaware.
Author contributions: Gavkare AM, Nanaware NL, Darade R, Dhotre SV, and Mumbare SS contributed to the discussion and design of the manuscript; Gavkare AM and Nanaware NL contributed equally to this manuscript as co-first authors; Nagoba BS designed the overall concept and outline of the manuscript; Nagoba BS and Gavkare AM contributed to the writing, editing the manuscript and review of literature. All authors contributed to finalising the manuscript.
AI contribution statement: ChatGPT was used only for language polishing purposes. No other AI tool used.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Basavraj S Nagoba, Assistant Dean, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. basavraj.nagoba@mimsr.edu.in
Received: February 7, 2026 Revised: March 3, 2026 Accepted: April 8, 2026 Published online: June 6, 2026 Processing time: 104 Days and 12.8 Hours
Core Tip
Core Tip: Rare and complex clinical cases require multidisciplinary team collaboration and integration of innovative research to achieve optimal outcomes. This systematic review highlights how multidisciplinary team-driven strategies, precision medicine, artificial intelligence, and novel therapeutics are transforming case management, improving patient survival and quality of life, and advancing global clinical practice. Though long-term outcome evidence remains limited, process-level benefits and integration of innovative technologies establish multidisciplinary teams as central to modern complex care. Strengthening the evidence base through standardized, high-quality research is essential to optimize implementation and improve patient outcomes.
