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World J Clin Cases. Apr 6, 2026; 14(10): 119088
Published online Apr 6, 2026. doi: 10.12998/wjcc.v14.i10.119088
Published online Apr 6, 2026. doi: 10.12998/wjcc.v14.i10.119088
Clinical consequences of the co-occurence of BRCA2 and NF1 mutation in ovarian cancer: A case report
Ewa Czukiewska, Agnieszka Kuźniar, Faculty of Medicine, The John Paul II Catholic University of Lublin, Lublin 20-708, Poland
Dominika Narowska, Third Department of Psychiatry, Institute of Psychiatry and Neurology in Warsaw, Warszawa 02-957, Poland
Tymoteusz Czukiewski, Faculty of Medicine, Medical University of Lublin, Lublin 20-059, Poland
Ilona Pasieka, Medical Laboratory, 1st Military Clinical Hospital with the Outpatient Clinic, Lublin 20-049, Poland
Author contributions: Czukiewska E, Narowska D, and Kuźniar A conceptualized and designed the research; Czukiewska E and Czukiewski T screened patients and acquired clinical data; Pasieka I collected blood specimen and performed laboratory analysis; Czukiewska E, Narowska D, and Kuźniar A performed data analysis; Czukiewska E, Narowska D, Czukiewski T, and Kuźniar A wrote the paper; and all the authors have read and approved the final manuscript; Czukiewska E was responsible for patient screening, enrollment, collection of clinical.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Ewa Czukiewska, Adjunct Associate Professor, Faculty of Medicine, The John Paul II Catholic University of Lublin, Ul. Konstantynów 1J, Lublin 20-708, Poland.
Received: January 21, 2026
Revised: February 9, 2026
Accepted: March 4, 2026
Published online: April 6, 2026
Processing time: 73 Days and 11.1 Hours
Revised: February 9, 2026
Accepted: March 4, 2026
Published online: April 6, 2026
Processing time: 73 Days and 11.1 Hours
Core Tip
Core Tip: This case underscores the clinical significance of dual pathogenic variants in neurofibromatosis type 1 and BRCA2, suggesting potential synergistic effects on early tumorigenesis and tumor biology. It highlights the importance of comprehensive genetic testing in complex hereditary cancer presentations, as well as multidisciplinary surveillance, and individualized risk-reduction strategies.