©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2025; 13(29): 108411
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.108411
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.108411
Low salivary uric acid levels and periodontitis: New insights and implications for clinical practice
Zhuo-Qun Hu, Department of Stomatology, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Yong Wang, Department of Internal Medicine, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Author contributions: Wang Y contributed to conception and design; Hu ZQ contributed to literature search and writing; All of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Yong Wang, Researcher, Yanbian University Hospital, No. 1327 Ju Zi Road, Yanji 133000, Jilin Province, China. wangyong0327ybu@163.com
Received: April 14, 2025
Revised: May 23, 2025
Accepted: July 22, 2025
Published online: October 16, 2025
Processing time: 137 Days and 3.1 Hours
Revised: May 23, 2025
Accepted: July 22, 2025
Published online: October 16, 2025
Processing time: 137 Days and 3.1 Hours
Core Tip
Core Tip: This letter explores the relationship between low salivary uric acid levels and periodontitis, revealing a significant independent association and inverse correlation with disease severity. Salivary uric acid emerges as a potential biomarker for disease progression, offering new insights into the pathophysiology of periodontitis and paving the way for innovative diagnostic and therapeutic strategies in clinical practice.