Effective application of an innovative acemannan-enriched glycolipid sphere dressing in diabetic foot ulcer wound healing: A case report and review of literature

doi:10.12998/wjcc.v13.i28.109358

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Oct 6, 2025 (publication date) through Aug 7, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Cases. Oct 6, 2025; 13(28): 109358
Published online Oct 6, 2025. doi: 10.12998/wjcc.v13.i28.109358

Effective application of an innovative acemannan-enriched glycolipid sphere dressing in diabetic foot ulcer wound healing: A case report and review of literature

Shu-Ting Mei, Jie-Jing Li

Shu-Ting Mei, Department of Clinical, Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou 510000, Guangdong Province, China

Jie-Jing Li, Department of Research, Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou 510000, Guangdong Province, China

Author contributions: Mei ST contributed to manuscript writing and editing, and data collection; Li JJ contributed to conceptualization and supervision; both authors have read and approved the final manuscript.

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jie-Jing Li, PhD, Associate Professor, Department of Research, Guangzhou Oriplamacy Technology Co., Ltd., No. 918 Middle Guangzhou Avenue, Guangzhou 510000, Guangdong Province, China. jiejingli@ext.jnu.edu.cn

Received: May 9, 2025
Revised: June 16, 2025
Accepted: July 15, 2025
Published online: October 6, 2025
Processing time: 91 Days and 5.6 Hours

Core Tip

Core Tip: This study reports the successful use of an acemannan-enriched glycolipid sphere dressing derived from aloe vera gel for treating a severe diabetic foot ulcer (DFU). An 80-year-old female with long-standing type 2 diabetes mellitus, presented with a nonhealing DFU (Texas classification: Grade II, stage D). Treatment involved applying the dressing five times daily, later reduced to three times after scab formation, alongside lifestyle management. Complete healing occurred within 5 months without significant scarring or functional loss, and no recurrence was observed during two years of follow-up. This case highlights the potential of acemannan-enriched dressings for DFU and other refractory wound treatments.