Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2025; 13(28): 107759
Published online Oct 6, 2025. doi: 10.12998/wjcc.v13.i28.107759
Magnetic resonance imaging spectrum of acute hemorrhagic leukoencephalitis: Four case reports
Ankit Shukla, Nishant Nayyar, Pooja Kumari, Ankush Kumar, Preeti Takkar
Ankit Shukla, Department of Surgery, Dr Rajendra Prasad Government Medical College, Kangra 176001, Himachal Pradesh, India
Nishant Nayyar, Pooja Kumari, Ankush Kumar, Preeti Takkar, Department of Radiology, Dr Rajendra Prasad Government Medical College, Kangra 176001, Himachal Pradesh, India
Co-corresponding authors: Ankit Shukla and Nishant Nayyar.
Author contributions: All the authors did the literature search. Shukla A and Nayyar N wrote the first draft of the review, played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; Nayyar N, Kumari P, Kumar A and Takkar P conceptualised the work, supervised the writing, and gave intellectual inputs. All the authors critically revised the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ankit Shukla, Assistant Professor, Department of Surgery, Dr Rajendra Prasad Government Medical College, Tanda at Kangra Himachal Pradesh, Kangra 176001, Himachal Pradesh, India. nkitshukla@yahoo.com
Received: March 30, 2025
Revised: April 22, 2025
Accepted: July 4, 2025
Published online: October 6, 2025
Processing time: 132 Days and 1.3 Hours
Core Tip

Core Tip: Acute hemorrhagic leukoencephalitis (AHLE) is a rapidly progressive demyelinating disorder often triggered by a viral infection. It involves widespread inflammation and bleeding in the brain, leading to neurological deterioration. Early recognition of symptoms such as confusion, seizures, or motor deficits is essential. Imaging studies, particularly magnetic resonance imaging (MRI), plays a vital role in diagnosis and monitoring treatment response. Timely administration of corticosteroids, immunosuppressive therapy, and supportive care can help manage the inflammation, reduce brain damage, and potentially improve prognosis.