Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2025; 13(27): 108117
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.108117
Unraveling the enigma of salivary uric acid in periodontitis: Independent association, mechanistic insights, and future trajectories
Dan-Dan Shi, Jing Ding, Ju Tian
Dan-Dan Shi, Jing Ding, Department of Plastic Surgery, Zhongshan City People’s Hospital, Zhongshan 528400, Guangdong Province, China
Ju Tian, Department of Burns and Plastic Surgery, Zhongshan City People’s Hospital, Zhongshan 528400, Guangdong Province, China
Co-first authors: Dan-Dan Shi and Jing Ding.
Author contributions: Tian J served as the designer of the overall concept and outline of the manuscript; Shi DD and Ding J collaborated on the writing and editing of the manuscript, the creation of illustrations, and the review of the relevant literature.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ju Tian, Department of Burns and Plastic Surgery, Zhongshan City People’s Hospital, Sunwen East Road, Zhongshan 528400, Guangdong Province, China. tian-ju@163.com
Received: April 7, 2025
Revised: May 17, 2025
Accepted: June 17, 2025
Published online: September 26, 2025
Processing time: 122 Days and 5.5 Hours
Core Tip

Core Tip: This article delves into salivary uric acid's (UA) dual role in periodontitis—antioxidant under normal conditions and pro-inflammatory under pathology. Studies show an inverse link between UA levels and periodontitis severity, with 111 nmol/mL as a diagnostic marker. Future research should prioritize longitudinal validation, multi-omics analysis, and therapeutic strategies.