Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2025; 13(26): 107716
Published online Sep 16, 2025. doi: 10.12998/wjcc.v13.i26.107716
Monitoring high-risk patients for chemotherapy-related cardiotoxicity: A retrospective analysis
Arnold Méndez-Toro, Felipe Alejandro Muñoz-Rossi, Rafael Enrique Tejada-Cabrera, Ingrid Tatiana Rojas-Ruiz, Juan David Flechas-Ardila, Alejandro García-Gutiérrez, Ricardo Andrés Novoa-Álvarez
Arnold Méndez-Toro, Department of Cardiology, Hospital Universitario Nacional de Colombia, Bogotá 111321, Colombia
Felipe Alejandro Muñoz-Rossi, Rafael Enrique Tejada-Cabrera, Department of Internal Medicine, Hospital Universitario Nacional de Colombia, Bogotá 111321, Colombia
Ingrid Tatiana Rojas-Ruiz, Faculty of Nursing, Universidad Nacional de Colombia, Bogotá 111321, Colombia
Juan David Flechas-Ardila, Alejandro García-Gutiérrez, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111321, Colombia
Ricardo Andrés Novoa-Álvarez, Research and Innovation Center, Fundación Universitaria Navarra, Neiva 410001, Huila, Colombia
Co-corresponding authors: Arnold Méndez-Toro and Ricardo Andrés Novoa-Alvarez.
Author contributions: Muñoz Rossi FA, Méndez Toro A, and Tejada R planned, organized, supervised, and executed the project; Muñoz Rossi FA was responsible for data collection; Rojas Ruiz IT was responsible for statistical analysis; and Novoa-Alvarez Ricardo A, García Gutiérrez A and Flechas Ardila JD contributed significantly to the interpretation of results and the preparation of the final manuscript; All authors have read and approved the manuscript. Both Méndez A and Novoa R made crucial and indispensable contributions to the completion of the project, which qualifies them as co-corresponding authors. Méndez A primarily contributed thematic and scientific perspective, offering deep insight and expertise that shaped the theoretical underpinnings of the manuscript and ensured the scientific rigor of the study. Novoa R, was responsible for the methodological and analytical aspects, leading the data interpretation and ensuring that the results were robust and appropriately aligned with the study’s objectives. While Méndez A’s thematic expertise guided the overall scientific approach and the manuscript submission, due to his clinical responsibilities, Novoa R took on the primary role in managing correspondence with the editors. Novoa’s availability and engagement in academic activities ensured a continuous and effective line of communication, thereby facilitating the editorial process. This shared and complementary leadership in both the scientific and editorial aspects of the work justify their joint role as co-corresponding authors.
Institutional review board statement: This investigation was approved by the Institutional Ethics Committee of National University of Colombia, No. 015-155.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this study. The study was conducted independently without external funding.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arnold Méndez-Toro, Professor, Department of Cardiology, Hospital Universitario Nacional de Colombia, Cardiology Unit, Universidad Nacional de Colombia, Bogotá, Colombia, Bogotá 111321, Colombia. arnold.mendez@hun.edu.co
Received: April 1, 2025
Revised: April 25, 2025
Accepted: June 13, 2025
Published online: September 16, 2025
Processing time: 117 Days and 15.5 Hours
Core Tip

Core Tip: Cardiotoxicity remains a significant concern for cancer patients undergoing high-risk chemotherapy. This study was conducted at the National University Hospital of Colombia and highlights the importance of echocardiography and biomarkers in detecting chemotherapy-induced cardiac damage. Among 195 patients analyzed, 8.7% developed cardiotoxicity, with significant declines in left ventricular ejection fraction and longitudinal strain. While biomarker usage showed variability, they show clear potential in early detection. The results underscore the critical need for standardized protocols to enhance the early detection and management of cardiotoxicity, enabling timely interventions and improved patient outcomes. This study advances the understanding of cardiotoxicity risk and management, advocating for structured multidisciplinary programs to optimize care.