Chronic renal insufficiency and Nocardia brasiliensis infection: A call for heightened vigilance and multidisciplinary management

doi:10.12998/wjcc.v13.i24.108115

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Clin Cases. Aug 26, 2025; 13(24): 108115
Published online Aug 26, 2025. doi: 10.12998/wjcc.v13.i24.108115

Chronic renal insufficiency and Nocardia brasiliensis infection: A call for heightened vigilance and multidisciplinary management

Jing Ding, Dan-Dan Shi, Ju Tian

Jing Ding, Dan-Dan Shi, Department of Plastic Surgery, Zhongshan City People’s Hospital, Zhongshan 528400, Guangdong Province, China

Ju Tian, Department of Burns and Plastic Surgery, Zhongshan City People’s Hospital, Zhongshan 528400, Guangdong Province, China

Co-first authors: Jing Ding and Dan-Dan Shi.

Author contributions: Ding J and Shi DD contributed equally to this work as co-first authors. Ding J and Shi DD provided crucial and indispensable contributions to the completion of this project; Tian J designed the overall concept and manuscript outline.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ju Tian, Department of Burns and Plastic Surgery, Zhongshan City People’s Hospital, Sunwen East Road, Zhongshan 528400, Guangdong Province, China. tian-ju@163.com

Received: April 7, 2025
Revised: April 23, 2025
Accepted: May 13, 2025
Published online: August 26, 2025
Processing time: 72 Days and 3.2 Hours

Core Tip

Core Tip: This study highlights the interplay of chronic renal insufficiency and Nocardia brasiliensis infection in immunocompromised patients. A tailored low-dose sulfamethoxazole-trimethoprim regimen with pharmacokinetic monitoring improved outcomes in a geriatric patient. Future research needs advanced diagnostics, biomarker development, and global epidemiological studies.