Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2025; 13(24): 105923
Published online Aug 26, 2025. doi: 10.12998/wjcc.v13.i24.105923
Combination of next-generation sequencing and traditional examinations for identifying Leuconostoc garlicum: A case report
Dan-Yang Zang, Lu-Guang Li, Shu-Guang Yang, Yuan-Yuan Wang, Xue-Qing Yu
Dan-Yang Zang, Lu-Guang Li, Shu-Guang Yang, Xue-Qing Yu, Department of Respiratory, The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, Henan Province, China
Yuan-Yuan Wang, Department of Bronchoscopy, The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, Henan Province, China
Co-first authors: Dan-Yang Zang and Lu-Guang Li.
Author contributions: Zang DY and Li LG contributed equally to this study as co-first authors. These two authors made equal significant contributions to the work and share equal responsibility and accountability for it. Zang DY and Yu XQ contributed to planning the diagnosis and treatment; Yang SG and Wang YY collected histopathological data; Zang DY organized the data and created the figures; Li LG drafted the manuscript; All authors contributed to manuscript revision and have read and approved the version for publication.
Informed consent statement: Informed written statement was obtained from the patient for publication of this report.
Conflict-of-interest statement: All the authors have approved this study, and there are no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Qing Yu, Chief Physician, MD, Professor, Department of Respiratory, The First Affiliated Hospital of Henan University of CM, No. 19 Renmin Road, Zhengzhou 450000, Henan Province, China. yxqshi@163.com
Received: February 11, 2025
Revised: April 12, 2025
Accepted: May 10, 2025
Published online: August 26, 2025
Processing time: 125 Days and 16.4 Hours
Core Tip

Core Tip: We report a case of Leuconostoc garlicum infection with persistent fever accompanied by fatigue. For patients with fever of unknown origin as the primary manifestation, comprehensive physical examination and thorough medical history are essential to minimize the risk of a missed or incorrect diagnosis. For most patients with fever caused by infection, conventional anti-infective treatment can lead to recovery. However, special attention should be paid to patients with rare or drug-resistant bacterial infections, whose diagnosis and treatment may be more difficult. Next-generation sequencing technology may provide support for the diagnosis and treatment of these patients.