Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2025; 13(20): 104953
Published online Jul 16, 2025. doi: 10.12998/wjcc.v13.i20.104953
Chronic renal insufficiency complicated by skin infection with Nocardia brasiliensis: A case report
Shan-Shan Zhang, Ying Lu, Wen-Ning Fu
Shan-Shan Zhang, College of Integrated Traditional Chinese and Western Medicine Clinical Medicine, Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University, Hangzhou 310012, Zhejiang Province, China
Ying Lu, Department of Nephrology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Wen-Ning Fu, Department of Nephrology and Rheumatology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China
Author contributions: Zhang SS contributed to conceptualization, methodology, data curation and analysis, writing the original draft, and visualization; Fu WN contributed to data acquisition and supervision; Lu Y contributed to writing the review and editing; and all authors have read and approved the final manuscript.
Supported by Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program, No. 2023ZF075.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Lu, MS, Chief Physician, Department of Nephrology, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. hz_luying@126.com
Received: January 7, 2025
Revised: February 25, 2025
Accepted: March 17, 2025
Published online: July 16, 2025
Processing time: 92 Days and 16.2 Hours
Core Tip

Core Tip: This report presents a case of primary cutaneous nocardiosis in a 93-year-old man with chronic renal insufficiency. The patient was hospitalized for immunodeficiency evaluation. After confirming infection with Nocardia brasiliensis, we initiated a low-dose treatment strategy to mitigate potential liver and kidney damage. The dosage was adjusted over time based on blood drug concentration monitoring. The patient experienced no recurrence of the rash.