Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2025; 13(19): 101850
Published online Jul 6, 2025. doi: 10.12998/wjcc.v13.i19.101850
Total adenosine deaminase cases as an inflammatory biomarker of pleural effusion syndrome
Bernardo Henrique Ferraz Maranhão, Cyro Teixeira da Silva Junior, Jorge Luiz Barillo, Joeber Bernardo Soares Souza, Patricia Siqueira Silva, Roberto Stirbulov
Bernardo Henrique Ferraz Maranhão, Department of Specialized Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro 20270004, State of Rio de Janeiro, Brazil
Cyro Teixeira da Silva Junior, Medical Clinics, Federal Fluminense University, Niteroi 24020080, Rio de Janeiro, Brazil
Jorge Luiz Barillo, Department of Thoracic Surgery, General Hospital Santa Teresa, Petropolis 25680-003, Rio de Janeiro, Brazil
Joeber Bernardo Soares Souza, Medical Clinics, Antonio Pedro University Hospital, Niteroi 24020-080, Rio de Janeiro, Brazil
Patricia Siqueira Silva, Professor Mazzini Bueno Tuberculosis Research and Assistance Center, Federal Fluminense University, Niteroi 24020-080, Rio de Janeiro, Brazil
Roberto Stirbulov, Department of Clinics, Rua Baronesa de Itu, São Paulo 1231001, São Paulo, Brazil
Author contributions: Maranhão BHF and Stirbulov R executed the idea and planned, organized, and supervised the study; Souza JBS, Barillo JL, and Silva PS were responsible for data collection; da Silva Junior CT wrote the earlier and final drafts of the manuscript and was responsible for statistical analysis and interpretation of the results. All authors have read and approved the manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Faculty of Medicine, Federal Fluminense University (number 48946121.9.0000.5243).
Informed consent statement: Written informed consent was obtained from all participants before the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest regarding the content of this article. Funding The authors received no financial support for the research, authorship, or publication of this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: sharing statement: The corresponding author can provide datasets that support the conclusions of this study upon request. The original datasets are not accessible to the general public because they contain data that may jeopardize the privacy of research participants.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cyro Teixeira da Silva Junior, MD, PhD, Full Professor, Medical Clinics, Federal Fluminense University, 13 Conceição Avenue, State of Rio de Janeiro, Niteroi 24020080, Rio de Janeiro, Brazil. ctsilvajunior@predialnet.com.br
Received: September 28, 2024
Revised: November 4, 2024
Accepted: March 4, 2025
Published online: July 6, 2025
Processing time: 171 Days and 17.7 Hours
Core Tip

Core Tip: Non-specialists find it difficult to diagnose pleural effusions. Although diagnosing the syndrome through imaging is simple, determining the cause is more difficult. To treat pleural disease as soon as possible, it is crucial to determine whether it is inflammatory. To our knowledge, this study is the first in Brazil and the world to establish a reference value with strict statistical criteria to classify inflammatory pleural effusion syndrome.