©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2025; 13(1): 93826
Published online Jan 6, 2025. doi: 10.12998/wjcc.v13.i1.93826
Published online Jan 6, 2025. doi: 10.12998/wjcc.v13.i1.93826
New exploration on pathogenesis and early diagnosis of gestational diabetes
Hua Bai, Department of Neurology, The Third Affiliated Hospital of Guizhou Medical University, Duyun 558099, Guizhou Province, China
Author contributions: Bai H study conception and design, data collection, paper writing and paper revision.
Supported by National Natural Science Foundation of China, No. 32060182; and Qiannan Prefecture Science and Technology Plan Project in China: Qiannan Kehe She Zi [2022] No. 1.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Hua Bai, MD, PhD, Chief, Full Professor, Department of Neurology, The Third Affiliated Hospital of Guizhou Medical University, No. 172 JianJiangbei Road, Duyun 558099, Guizhou Province, China. baih2020@gmc.edu.cn
Received: March 6, 2024
Revised: July 22, 2024
Accepted: July 25, 2024
Published online: January 6, 2025
Processing time: 245 Days and 22.9 Hours
Revised: July 22, 2024
Accepted: July 25, 2024
Published online: January 6, 2025
Processing time: 245 Days and 22.9 Hours
Core Tip
Core Tip: Pancreas β cellular damage and tissue insulin resistance are key to the pathogenesis of gestational diabetes mellitus (GDM). Once beta cell dysfunction begins, hyperglycemia, insulin resistance, and further beta cell dysfunction are likely to enter a vicious cycle. Introducing advanced biotechnology such as proteomics for basic research on GDM is a good attempt. RBP4 and ANGPTL8 proteins may play a role in the pathogenesis of GDM, but there is insufficient evidence to diagnose GDM by detecting the two proteins.