MiRNA-200a and miRNA-200b expression, and vitamin-D level: Prognostic significance in obese non-diabetic and obese type 2 diabetes mellitus individuals

doi:10.12998/wjcc.v12.i36.6916

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Dec 26, 2024; 12(36): 6916-6925
Published online Dec 26, 2024. doi: 10.12998/wjcc.v12.i36.6916

MiRNA-200a and miRNA-200b expression, and vitamin-D level: Prognostic significance in obese non-diabetic and obese type 2 diabetes mellitus individuals

Abrar Fahad Alshahrani, Fauzia Ashfaq, Abdulrahman A Alsayegh, Mohammed Bajahzer, Mohammad Idreesh Khan, Mirza Masroor Ali Beg

Abrar Fahad Alshahrani, Fauzia Ashfaq, Abdulrahman A Alsayegh, Mohammed Bajahzer, Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan 82817, Saudi Arabia

Mohammad Idreesh Khan, Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, P.O. Box 6666 Saudi Arabia

Mirza Masroor Ali Beg, Faculty of Medicine, Alatoo International University, Bishkek 720048, Kyrgyzstan

Author contributions: Alshahrani AF, Ashfaq F contributed to the concept, methodology, experimentation and data collection, corrections after revision, and reading before submission; Alsayegh AA, Bajahzer M contributed to data entry, produced the first draft, and reading before submission; Khan MI, Beg MMA contributed to data analysis, writing and corrections after revision, and reading before submission.

Supported by The Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, for funding this research work through the project number ISP-24., Jazan University, Jazan 82817, Saudi Arabia.

Institutional review board statement: This study was ethically approved by the Research Ethics Committee, Ministry of Health, (Reg. No: 607-43-1478), Saudi Arabia.

Informed consent statement: Informed consent was obtained from all study participants.

Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.

Data sharing statement: Data may be available by contacting the corresponding author upon request.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.

Corresponding author: Mirza Masroor Ali Beg, PhD, Associate Professor, Faculty of Medicine, Alatoo International University, 1/8 Ankara Street, Bishkek 720048, Kyrgyzstan. mirzamasroor1986@gmail.com

Received: June 13, 2024
Revised: September 18, 2024
Accepted: October 9, 2024
Published online: December 26, 2024
Processing time: 140 Days and 0.5 Hours

Core Tip

Core Tip: Obesity and being overweight are widespread health issues in modern societies, and their growing prevalence poses a serious public health challenge due to both the financial burden and health risks involved. In humans, the expression of miRNAs in adipose tissue has been demonstrated to be associated with various metabolic factors, including body mass index, adipogenesis, blood sugar levels, and leptin concentrations. The microRNA (miRNA)-200 family is reported to be more prevalent in human β-cells than in α-cells. The expression of miRNA-200a and miRNA-200b is regulated by thioredoxin-interacting protein, a proapoptotic regulator. It has been suggested that a deficiency in vitamin D is closely associated with obesity and plays a role in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Studies have indicated that vitamin D influences the expression of miRNAs both in adipocytes in laboratory settings and in adipose tissue in living organisms. Therefore, the current work examines miRNA-200a and miRNA-200b expression, and vitamin-D level in obese non-diabetic and obese T2DM individuals.