Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2024; 12(35): 6859-6863
Published online Dec 16, 2024. doi: 10.12998/wjcc.v12.i35.6859
Role of high-dose amoxicillin dual therapy for Helicobacter pylori eradication in an Irish cohort: A prospective study
Raffaele Palmirotta, Concetta Cafiero, Marica Colella
Raffaele Palmirotta, Marica Colella, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Bari 70124, Italy
Concetta Cafiero, Area of Molecular Pathology, Anatomic Pathology Unit, Fabrizio Spaziani Hospital, Frosinone 03100, Italy
Author contributions: Palmirotta R, Cafiero C and Colella M contributed to this paper; Palmirotta R designed the overall concept and outline of the manuscript; Palmirotta R and Colella M contributed to the discussion and design of the manuscript; Palmirotta R, Colella M and Cafiero C contributed to the writing, editing the manuscript, and review of the literature; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raffaele Palmirotta, MD, PhD, Associate Professor, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, P.zza G. Cesare, 11, Bari 70124, Italy. raffaelepalmirotta@gmail.com
Received: May 18, 2024
Revised: September 19, 2024
Accepted: October 9, 2024
Published online: December 16, 2024
Processing time: 158 Days and 16.8 Hours
Core Tip

Core Tip: Costigan et al conducted a prospective study to test high-dose amoxicillin dual therapy (HDADT) for Helicobacter pylori infections in an Irish cohort. Ireland is a high dual-resistance country for clarithromycin and metronidazole, so the traditional treatment does not work well. In addition, bismuth is not available in Ireland; therefore, the only recommended treatment is HDADT. The study considered in this editorial is the first to be conducted in Ireland, and it shows that HDADT does not always guarantee bacterial eradication.