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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2024; 12(35): 6826-6833
Published online Dec 16, 2024. doi: 10.12998/wjcc.v12.i35.6826
Published online Dec 16, 2024. doi: 10.12998/wjcc.v12.i35.6826
psk1 virulence gene-induced pulmonary and systemic tuberculosis in a young woman with normal immune function: A case report
Fan Wu, Yu-Sheng Chen, Department of Respiratory and Critical Care Medicine, Shengli Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, Fujian Province, China
Bin Yang, Yan Xiao, Li-Li Ren, NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Hong-Yi Chen, Emergency Department, Shengli Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, Fujian Province, China
Xin-Lan Hu, Clinical Microbiology Laboratory, Shengli Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, Fujian Province, China
Yan-Yu Pan, Infection Department, The 900th Hospital of the PLA Joint Support Force, Fuzhou 350001, Fujian Province, China
Hong-Ru Li, Department of Infectious Diseases, Shengli Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, Fujian Province, China
Author contributions: Wu F, Yang B, Xiao Y, and Chen H contributed to conceptualisation, supervision, evaluation, and manuscript writing and editing; Yang B, Hu X, and Pan Y contributed to methodology; Ren L, Chen Y, and Li H contributed to manuscript writing and editing; All authors have read and approved the final manuscript.
Supported by the Research on Intelligent Recommendation Decision Model of Geriatrics Based on Big Data , No. 2021CX01010136 .
Informed consent statement: The patient provided written informed consent to publish this case study and accompanying images.
Conflict-of-interest statement: All authors report no conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Ru Li, MD, PhD, Chief Doctor, Professor, Department of Infectious Diseases, Shengli Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, No. 134 East Street, Fuzhou 350001, Fujian Province, China. muzi131122@163.com
Received: January 2, 2024
Revised: July 2, 2024
Accepted: July 23, 2024
Published online: December 16, 2024
Processing time: 295 Days and 18 Hours
Revised: July 2, 2024
Accepted: July 23, 2024
Published online: December 16, 2024
Processing time: 295 Days and 18 Hours
Core Tip
Core Tip: Tuberculosis is an important public health problem that threatens human health that primarily infects the lungs. We report a case of invasive pulmonary tuberculosis in a young woman with normal immune function. Comparison of the genetic characteristics of the patient’s strain with those of other disease-causing strains suggests that its virulence and wide dissemination was attributable to the presence of the pks1 gene, a genotype that can cause meningitis.