Recent developments in immunotherapy approaches for allergic rhinitis

doi:10.12998/wjcc.v12.i31.6451

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Nov 6, 2024; 12(31): 6451-6461
Published online Nov 6, 2024. doi: 10.12998/wjcc.v12.i31.6451

Recent developments in immunotherapy approaches for allergic rhinitis

Yu Fu, Yi-Lai Song, Zhong-Guo Liu

Yu Fu, Yi-Lai Song, Zhong-Guo Liu, Drug Clinical Trial Unit, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China

Author contributions: Fu Y contributed to the manuscript conceptualization, manuscript preparation, methodology, and the final revision of the manuscript; Fu Y and Song YL contributed to the data curation; Liu ZG contributed to the manuscript revision. All authors have read and agreed to the published version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Zhong-Guo Liu, MD, Professor, Drug Clinical Trial Unit, First Hospital of Shanxi Medical University, No. 13 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. lzg1810@163.com

Received: March 14, 2024
Revised: July 22, 2024
Accepted: August 16, 2024
Published online: November 6, 2024
Processing time: 181 Days and 3.4 Hours

Core Tip

Core Tip: This comprehensive review thoroughly examines various immunotherapeutic pathways. Each pathway is systematically elucidated, with its distinctive features, mechanisms, and clinical implications highlighted. The review critically assesses the epidemiological landscape of allergic rhinitis, shedding light on its diverse regional characteristics and influencing factors. Furthermore, combining immunotherapy with antibody therapy signifies a promising frontier in severe allergic rhinitis treatment. The review outlines relevant indicators for predicting immunotherapy efficacy, emphasizing the importance of identifying immune cells, cytokines, metabolites, and metabolic pathways associated with treatment outcomes. Despite the proven benefits of immunotherapy, the review candidly addresses its limitations.