Deciphering the iron enigma: Navigating the complexities of iron metabolism in critical illness

Core Tip

Core Tip: Traditionally serum iron parameters including ferritin have served as biomarkers for assessing the iron status. Recently, the spectrum of utility for these markers has widened as tools for assessing inflammation and predicting outcomes in critically ill patients. These markers have been associated with high mortality and poor clinical outcomes in various critical illnesses. Serial measurement of iron parameters, especially in patients admitted to intensive care units, may be used as potential tools to determine worsening and progression towards multiorgan failure. However, their interpretation must be in accordance with the patient's clinical condition and other biochemical parameters, for guiding further treatment to optimize clinical care and prognosis.