Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2024; 12(25): 5832-5838
Published online Sep 6, 2024. doi: 10.12998/wjcc.v12.i25.5832
Omadacycline in the treatment of scrub typhus: Three case reports
Xue-Mei Lang, Yun Qiu, Ya-Juan Jia, Hong Sun, Su-Min Gao, Hong-Mei Zhao
Xue-Mei Lang, Yun Qiu, Ya-Juan Jia, Hong Sun, Su-Min Gao, Hong-Mei Zhao, Department of Emergency Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai’an 223000, Jiangsu Province, China
Co-corresponding authors: Su-Min Gao and Hong-Mei Zhao.
Author contributions: Lang XM, Gao SM, and Zhao HM collectively identified the population of patients of scrub typhus and, together with Sun H, defined the research objectives and methodology; Lang XM was responsible for patient communication; Lang XM, Qiu Y, and Jia YJ collaborated on collecting medical data, taking photographs, and creating charts, and extensively discussed the conclusions of this study; Lang XM, Gao SM and Zhao HM drafted the manuscript together. All authors participated in reading, reviewing, discussing, and revising the manuscript, contributing significantly to the final version. Gao SM and Zhao HM are designated as co-corresponding authors for this paper. The rationale for appointing Gao SM and Zhao HM as co-corresponding authors lies in several factors: firstly, our team members represent diverse professional backgrounds and roles, and Gao SM and Zhao HM jointly guided the research, ensuring its comprehensiveness and depth. Secondly, Gao SM and Zhao HM undertook equal workloads during the study, exerting the same level of effort and fully engaging in all stages of the research. Selecting them as co-corresponding authors acknowledges their equal contributions and reflects our team's spirit of collaboration, comprehensiveness, and diversity.
Supported by National Natural Science Foundation of China, No. 81800721; and the Postdoctoral Foundation of China, 2020M671387.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared according to CARE checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Su-Min Gao, PhD, Associate Chief Physician, Department of Emergency Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai’an 223000, Jiangsu Province, China. gao666332@sina.com
Received: May 13, 2024
Revised: June 21, 2024
Accepted: July 4, 2024
Published online: September 6, 2024
Processing time: 64 Days and 15.7 Hours
Core Tip

Core Tip: Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi (O. tsutsugamushi). In the present work, we report three cases of scrub typhus, with the main clinical symptoms being fever, the formation of eschar or ulcers, local or systemic lymphadenopathy, headache, myalgia and rash. Blood samples were collected before the administration of omadacycline. Omadacycline can be considered an alternative option for anti infective therapy in patients with O. tsutsugamushi infections.