Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2024; 12(25): 5729-5738
Published online Sep 6, 2024. doi: 10.12998/wjcc.v12.i25.5729
Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer: A bidirectional Mendelian randomization study
Chun-Mei Lin, Qian Meng, Ying-Jun Li, Shuang-Xi Zhang, Qiong-Xi Luo, Zhen-Yu Dai
Chun-Mei Lin, Qian Meng, Ying-Jun Li, Qiong-Xi Luo, Zhen-Yu Dai, Postgraduate Student, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Shuang-Xi Zhang, Department of Gastroenterology, Guangzhou University of Chinese Medicine Shunde Hospital, Foshan 528300, Guangdong Province, China
Co-first authors: Chun-Mei Lin and Qian Meng.
Author contributions: Lin CM assisted with planning and directing the research, and writing, editing, and revising the manuscript and formal analysis; Meng Q, Li YJ, Luo QX and Dai ZY helped with the data collection; Zhang SX helped with the statistical analysis; All authors approved the final draft.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuang-Xi Zhang, BPhty, Chief Doctor, Department of Gastro-enterology, Guangzhou University of Chinese Medicine Shunde Hospital, No. 12 Jinsha Avenue, Daliang, Shunde District, Foshan 528300, Guangdong Province, China. zhangsx81@163.com
Received: April 22, 2024
Revised: May 27, 2024
Accepted: June 19, 2024
Published online: September 6, 2024
Processing time: 85 Days and 16.4 Hours
Core Tip

Core Tip: Higher ratios of cholesterol to total lipids in medium very-low-density lipoprotein (VLDL) levels were causally related to a reduced risk of peptic ulcer (PU) or the main pathways implicated in its development, as suggested by our Mendelian randomization investigation. Further laboratory studies and exploration of molecular mechanisms are required to clarify the role of the ratio of cholesterol to total lipids in medium VLDL in the onset of PU and its main pathways.