©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2024; 12(24): 5534-5541
Published online Aug 26, 2024. doi: 10.12998/wjcc.v12.i24.5534
Published online Aug 26, 2024. doi: 10.12998/wjcc.v12.i24.5534
Effect of dietary with Zhibai dihuang pills and gonadotropin-releasing-hormone-analogue on girls with precocious and rapidly progressive puberty
Xue-Mei Wang, Wei Li, Liu-Qing Yang, Rui Luo, Chen-Chen Zhang, Department of Pediatrics, Ma’anshan Maternal and Child Health Hospital, Ma’anshan 243011, Anhui Province, China
Author contributions: Wang XM contributed to the conceptualization, formal analysis, project administration, software, supervision, validation, visualization, writing-original draft, and writing-review & editing of this manuscript; Wang XM and Li W participated in the data curation; Wang XM, Li W, and Yang LQ took part in the investigation and methodology of this manuscript; Luo R and Zhang CC were involved in the resources.
Institutional review board statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by Institutional Review Board of Ma’anshan Maternal and Child Health Hospital.
Clinical trial registration statement: This study was registered at Ma’anshan Maternal and Child Health Hospital clinical trial registry. Hospital Clinical Trial Registry, Registration number: MASSFYBJY-LLWYH26.
Informed consent statement: All the study subjects provided informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data in this study can be obtained from the corresponding author upon reasonable request.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Corresponding author: Xue-Mei Wang, MM, Associate Chief Physician, Department of Pediatrics, Ma’anshan Maternal and Child Health Hospital, No. 446 Jiashan Road, Ma’anshan 243011, Anhui Province, China. xuemeiwang23@163.com
Received: May 31, 2024
Revised: June 24, 2024
Accepted: July 1, 2024
Published online: August 26, 2024
Processing time: 40 Days and 20.8 Hours
Revised: June 24, 2024
Accepted: July 1, 2024
Published online: August 26, 2024
Processing time: 40 Days and 20.8 Hours
Core Tip
Core Tip: Combining Zhibai dihuang pills with gonadotropin-releasing hormone analogue (GnRHa) and dietary intervention significantly improves growth outcomes and ovarian function in girls with precocious and rapidly progressive puberty. In this study, girls treated with this combination showed lower rates of growth and bone age advancement, along with reduced levels of key hormones, compared to a control group receiving only GnRHa and diet intervention. This study highlighted the enhanced efficacy and safety of the combined treatment and provides a promising intervention for managing precocious puberty.