Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2024; 12(21): 4550-4557
Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4550
Relationship of inflammatory indices with left atrial appendage thrombus or spontaneous echo contrast in patients with atrial fibrillation
Zhao Wang, Bin-Hao Wang, Xiao-Lei Yang, Yun-Long Xia, Sheng-Min Zhang, Ying Che
Zhao Wang, Ying Che, Department of Ultrasonography, First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Bin-Hao Wang, Arrhythmia Center, First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Xiao-Lei Yang, Yun-Long Xia, Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Sheng-Min Zhang, Department of Ultrasonography, First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Co-corresponding authors: Sheng-Min Zhang and Ying Che.
Author contributions: Wang Z, Wang BH, Zhang SM, and Che Y conceived, designed, and refined the study protocol; Wang Z and Wang BH were involved in the data collection; Wang Z, Wang BH, Zhang SM, and Che Y analyzed the data; Wang Z and Wang BH drafted the manuscript; all authors have read and approved the final manuscript. Zhang SM and Che Y were designated as co-corresponding authors for two reasons. First, the study was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the investigation and the resultant paper. Second, Zhang SM and Che Y contributed efforts of equal substance throughout the research process. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution. Therefore, we believe that designating Zhang SM and Che Y as co-corresponding authors is suitable for our manuscript as it accurately reflects our team's collaborative spirit and equal contributions.
Supported by Public Welfare Technology Project of Ningbo Science and Technology Bureau, No. 2023S140; and Medical Health Science and Technology Project of Zhejiang Province Health Commission, No. 2024KY1518.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Ningbo University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Che, MD, Professor, Department of Ultrasonography, First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116000, Liaoning Province, China. cheying@dmu.edu.cn
Received: March 17, 2024
Revised: May 13, 2024
Accepted: May 28, 2024
Published online: July 26, 2024
Processing time: 106 Days and 0.4 Hours
Core Tip

Core Tip: Atrial fibrillation (AF) increases the risk of ischemic stroke. One of the most powerful risk factors for ischemic stroke is the development of a thrombus and spontaneous echo contrast (SEC) in the left atrial appendage (LAA). Inflammatory state increases the propensity for thrombosis in AF patients. Therefore, we explored the value of inflammatory indices for predicting the presence of LAA thrombus or dense SEC. The results showed that some inflammatory indices derived from complete blood tests, including the neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio, may predict LAA thrombus or dense SEC in patients with nonvalvular AF.