Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2023; 11(7): 1549-1559
Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1549
Hyperthyroidism and severe bradycardia: Report of three cases and review of the literature
Yang-Li He, Wen-Xing Xu, Tuan-Yu Fang, Min Zeng
Yang-Li He, Wen-Xing Xu, Min Zeng, Center of Geriatrics, Hainan General Hospital, Haikou 570311, Hainan Province, China
Yang-Li He, Wen-Xing Xu, Min Zeng, Hainan Clinical Research Center for Cardiovascular Disease, Hainan General Hospital, Haikou 570311, Hainan Province, China
Yang-Li He, Min Zeng, Center of Geriatrics, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Tuan-Yu Fang, Department of Endocrine, Hainan General Hospital, Haikou 570311, Hainan Province, China
Author contributions: He YL and Zeng M contributed to manuscript writing and editing, and data collection; Xu WX and Fang TY contributed to data analysis; all authors have read and approved the final manuscript.
Supported by the Clinical Medical Research Center Project of Hainan Province, China, No. LCYX202207; and Key R&D Plan Project of Hainan Province, China, No. ZDYF2020118.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min Zeng, PhD, Chief Doctor, Professor, Center of Geriatrics, Hainan General Hospital, No. 19 Xiuhua Road, Haikou 570311, Hainan Province, China. hndzm6@126.com
Received: October 19, 2022
Peer-review started: October 19, 2022
First decision: December 26, 2022
Revised: January 13, 2023
Accepted: February 15, 2023
Article in press: February 15, 2023
Published online: March 6, 2023
Processing time: 133 Days and 22 Hours
Core Tip

Core Tip: Severe bradycardia, such as sick sinus syndrome and atrioventricular block, can occasionally be encountered in patients with hyperthyroidism. These pose a challenge for physicians. We report three cases of hyperthyroidism with severe bradycardia and identified an additional 31 cases indexed in PubMed. We found that hyperthyroidism with severe bradycardia may require 1 wk of observation before deciding whether to implant a permanent pacemaker. The use of drugs (e.g., atropine, isoproterenol, and/or anti-hyperthyroidism treatment), implantation of temporary pacemakers, and correcting the electrolyte disorder are recommended before permanent pacemaker implantation.