Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2023; 11(4): 844-851
Published online Feb 6, 2023. doi: 10.12998/wjcc.v11.i4.844
Metagenomic next-generation sequencing for pleural effusions induced by viral pleurisy: A case report
Xue-Ping Liu, Chen-Xue Mao, Guan-Song Wang, Ming-Zhou Zhang
Xue-Ping Liu, Guan-Song Wang, Ming-Zhou Zhang, Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Chen-Xue Mao, Department of Laboratory Diagnosis, Chongqing KingMed Center for Clinical Laboratory Co., Ltd, Chongqing 400050, China
Author contributions: Liu XP and Wang GS collected the clinical information; the manuscript was written by Liu XP and Mao CX, and revised by Zhang MZ.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: Author Chen-Xue Mao is employed by ChongQing KingMed Center for Clinical Laboratory Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Zhou Zhang, PhD, Professor, Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, No. 183 Xinqiaozheng Street, Chongqing 400037, China. mingzhou06@tmmu.edu.cn
Received: August 24, 2022
Peer-review started: August 24, 2022
First decision: December 13, 2022
Revised: December 31, 2022
Accepted: January 16, 2023
Article in press: January 16, 2023
Published online: February 6, 2023
Processing time: 157 Days and 17.2 Hours
Core Tip

Core Tip: Pleural effusion is a common clinical symptom, and infectious pleurisy is one of the reasons. Its pathogen is difficult to be found by microbiological examination, and the diagnosis of viral pleural effusion is particularly difficult. Epstein-barr virus is latent infection in most adults, and it is easy to be reactivated in people with immune deficiency, which may cause infection in all parts of the body. When idiopathic pleural effusion is not clearly diagnosed through routine examination, the possibility of viral infection should be considered, and early improvement of metagenomic next-generation sequencing examination is helpful for the diagnosis.