Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2023; 11(29): 7227-7233
Published online Oct 16, 2023. doi: 10.12998/wjcc.v11.i29.7227
Congenital leukemia: A case report and review of literature
Chun-Xia Yang, Ying Yang, Fen-Li Zhang, Ding-Huan Wang, Qiu-Han Bian, Man Zhou, Ming-Xiang Zhou, Xiao-Yan Yang
Chun-Xia Yang, Ying Yang, Fen-Li Zhang, Ding-Huan Wang, Qiu-Han Bian, Man Zhou, Ming-Xiang Zhou, Xiao-Yan Yang, Department of Pediatrics, Affiliated Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Chun-Xia Yang, Clinical Medicine, Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Author contributions: Yang CX and Yang Y carried out the studies and drafted the manuscript; Yang XY revised the manuscript; Wang DH and Bian QH collected the clinical data; Zhang FL, Zhou M and Zhou MX were responsible for the literature search; Yang CX and Yang XY contributed conception and design of the study; All authors have read and approved the final manuscript.
Supported by Project of Regional Science Foundation of National Natural Science Foundation, No. 82060033; Project of Scientific and Technological Innovation Talent Team in Guizhou Province, No. CXTD[2021]002.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Yang, PhD, Professor, Department of Pediatrics, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, Guiyang 550000, Guizhou Province, China. 469389553@qq.com
Received: August 15, 2023
Peer-review started: August 15, 2023
First decision: August 30, 2023
Revised: September 11, 2023
Accepted: September 19, 2023
Article in press: September 19, 2023
Published online: October 16, 2023
Processing time: 54 Days and 3.2 Hours
Core Tip

Core Tip: We documented a case of trisomy 21-related acute myeloid leukemia (AML) in a newborn baby. She was sent to the newborn critical care unit due to anorexia, poor responsiveness, and respiratory distress. She was diagnosed with AML based on bone marrow aspiration and immunophenotyping. Genetic sequencing identified a mutation in GATA1. Parents abandoned medical care for their child after receiving the diagnosis. The baby died at home.