Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2023; 11(26): 6252-6261
Published online Sep 16, 2023. doi: 10.12998/wjcc.v11.i26.6252
Difficulties in diagnosing angiomatoid fibrous histiocytoma of the head and neck region: A case report
Adam Michcik, Marta Bień, Barbara Wojciechowska, Adam Polcyn, Łukasz Garbacewicz, Jacek Kowalski, Barbara Drogoszewska
Adam Michcik, Marta Bień, Barbara Wojciechowska, Adam Polcyn, Łukasz Garbacewicz, Barbara Drogoszewska, Department of Maxillofacial Surgery, Medical University of Gdańsk, Gdańsk 80-214, Poland
Jacek Kowalski, Department of Pathomorphology, Medical University of Gdańsk, Gdańsk 80-214, Poland
Author contributions: Michcik A was the maxillofacial surgeon who treated the patient, contributed to editing and to supervision; Bień M and Wojciechowska B contributed to manuscript writing, data collection; Kowalski J made pathomorphological part; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marta Bień, MD, Doctor, Department of Maxillofacial Surgery, Medical University of Gdańsk, 17 Mariana Smoluchowskiego, Gdańsk 80-214, Poland. bienmartaa@gmail.com
Received: May 31, 2023
Peer-review started: May 31, 2023
First decision: August 10, 2023
Revised: August 16, 2023
Accepted: August 21, 2023
Article in press: August 21, 2023
Published online: September 16, 2023
Processing time: 99 Days and 14.9 Hours
Core Tip

Core Tip: Angiomatoid fibrous histiocytoma (AFH) is a rare neoplasm of soft tissues with an atypical location and a large morphological spectrum, and is considered a lesion with diagnostic difficulties. Auxiliary diagnostic tests in the field of molecular genetics are also important. The EWS RNA-binding protein 1-CREB-binding protein 1 t(2;22)(q33;q12) fusion assay is an extremely important diagnostic element that should be routinely performed in patients with AFH. In the case of gene translocations, we are obliged to increase the frequency of follow-up examinations. However, owing to the small number of clinical cases, it is difficult to predict the course of the disease and assess patient prognosis.