Systematic Reviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2023; 11(22): 5252-5272
Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5252
COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review
Reem Elbeltagi, Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy
Reem Elbeltagi, Department of Medicine, The Royal College of Surgeons in Ireland-Medical University of Bahrain, Busiateen ‎15503‎, Muharraq, Bahrain
Mohammed Al-Beltagi, Department of Paediatrics, Faculty of Medicine, Tanta University, Tanta ‎31511‎, Algharbia, Egypt
Mohammed Al-Beltagi, Department of Paediatrics, University Medical Center, Arabian Gulf University, Manama ‎26671‎, Manama, Bahrain
Mohammed Al-Beltagi, Department of Paediatrics, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Dr ‎Sulaiman Al Habib Medical Group, Manama ‎26671‎, Manama, Bahrain
Nermin Kamal Saeed, Medical Microbiology Section, Pathology Department, Salmaniya Medical Complex, Ministry of Health, Kingdom of Bahrain, Manama 12, Manama, Bahrain
Nermin Kamal Saeed, Microbiology Section, Pathology Department, The Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen 15503, Muharraq, Bahrain
Adel Salah Bediwy, Department of Chest Disease, Faculty of Medicine, Tanta University, Tanta ‎31527‎, Algharbia, Egypt
Adel Salah Bediwy, Department of Pulmonology, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Dr ‎Sulaiman Al Habib Medical Group, Manama ‎26671‎, Manama, Bahrain
Author contributions: Elbeltagi R, Al-Biltagi M, Saeed NK, and Bediwy AS contributed equally to this work; all the authors collaborated to collect the data, and write and revise the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
PRISMA 2009 Checklist statement: The manuscript was prepared and revised according to the PRISMA 2009 Checklist statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Al-Beltagi, MBChB, MD, MSc, PhD, Academic Editor, Chairman, Consultant Physician-Scientist, Professor, Researcher, Department of Paediatrics, Faculty of Medicine, Tanta University, AlBahr street, Tanta ‎31511‎, Algharbia, Egypt. mbelrem@hotmail.com
Received: April 20, 2023
Peer-review started: April 20, 2023
First decision: June 7, 2023
Revised: June 10, 2023
Accepted: July 3, 2023
Article in press: July 3, 2023
Published online: August 6, 2023
Processing time: 104 Days and 12.6 Hours
Core Tip

Core Tip: As a systemic disease, coronavirus disease 2019 (COVID-19) can impact various organs in the human body, including the autonomic nervous system and gastrointestinal tract. Our team conducted a systematic review to better understand the clinical range of COVID-19's impact on gastrointestinal autonomic dysfunction. We examined the clinical manifestations, potential mechanisms, diagnosis, differential diagnosis, effects on quality of life, prognosis, management, and prevention of COVID-19-induced gastrointestinal autonomic dysfunction. Most of the literature suggests that gastrointestinal autonomic dysfunction can be severe and negatively impact a patient's quality of life and prognosis. As a result, a multidisciplinary approach is needed to manage this dysfunction. However, further research is necessary to study COVID-19-induced gastrointestinal autonomic dysfunction effectively.