©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2023; 11(14): 3114-3127
Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3114
Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3114
Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach
Arushi Sandhu, Anil Kumar, Kajal Rawat, Vipasha Gautam, Antika Sharma, Lekha Saha, Department of Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 0172, Chandigarh, India
Author contributions: Sandhu A contributed to conceptualization, writing-original draft preparation, visualization and investigation, reviewing and editing; Kumar A, Rawat K and Sharma A wrote the original draft; Gautam V wrote the original draft and proofread; Saha L contributed to conceptualization, supervision, reviewing and editing.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Corresponding author: Lekha Saha, MBBS, MD, MNAMS, Full Professor, Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh 0172, Chandigarh, India. lekhasaha@rediffmail.com
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: January 30, 2023
Revised: February 13, 2023
Accepted: April 6, 2023
Article in press: April 6, 2023
Published online: May 16, 2023
Processing time: 139 Days and 5 Hours
Peer-review started: December 28, 2022
First decision: January 30, 2023
Revised: February 13, 2023
Accepted: April 6, 2023
Article in press: April 6, 2023
Published online: May 16, 2023
Processing time: 139 Days and 5 Hours
Core Tip
Core Tip: There are several reviews in the literature explaining the underlying mechanisms contributing to the pathophysiology of autism spectrum disorder by performing several preclinical experiments. Given the significant role of genetics (de novo or inheritable) in the development of autism spectrum disorder, disease specific models should be established for investigating the mechanism involved. Therefore, this review specifically focused on the use of an emerging genomic editing tool, clustered regularly inters-paced palindromic repeats/Cas9, for generating different types of preclinical models as well as new therapeutic options, providing a novel insight into the disease.