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World J Clin Cases. Apr 6, 2023; 11(10): 2140-2159
Published online Apr 6, 2023. doi: 10.12998/wjcc.v11.i10.2140
Diagnosis, treatment protocols, and outcomes of liver transplant recipients infected with COVID-19
Mohamed El-Kassas, Mai Hashem
Mai Hashem, Fellow of Tropical Medicine and Gastroenterology, Assiut University Hospital, Assiut 71515, Egypt
Mohamed El-Kassas, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo 11795, Egypt
Author contributions: Hashem M, and El-Kassas M contributed to the conception and design of the work, literature review, drafting and critical revision, editing, and approval of the final version of the manuscript.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Corresponding author: Mohamed El-Kassas, MD, Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Ain Helwan, Cairo 11795, Egypt. m_elkassas@hq.helwan.edu.eg
Received: September 2, 2022
Peer-review started: September 2, 2022
First decision: January 5, 2023
Revised: January 20, 2023
Accepted: March 9, 2023
Article in press: March 9, 2023
Published online: April 6, 2023
Processing time: 208 Days and 21.9 Hours
Core Tip

Core Tip: Liver transplant (LT) patients infected with severe acute respiratory syndrome coronavirus 2 have clinical, biochemical, and radiological features highly comparable to those of immunocompetent patients, except for a higher incidence of gastrointestinal symptoms. The prognosis of LT recipients is similar to non-LT patients and is not significantly affected by immunosuppression but rather by comorbidities. Considering the risk of organ rejection, it may not be wise to stop all immunosuppression after a coronavirus disease 2019 diagnosis. All LT recipients should be vaccinated, considering booster doses augment vaccination immunogenicity. Still, a considerable proportion of patients remain at risk for coronavirus disease 2019. Therefore, social isolation and other precautions must be maintained.