Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2022; 10(9): 2783-2791
Published online Mar 26, 2022. doi: 10.12998/wjcc.v10.i9.2783
Overexpression of Ubiquilin4 is associated with poor prognosis in patients with cervical cancer
Li-Na Wang, Ke-Jin Huang, Le Wang, Hai-Yan Cheng
Li-Na Wang, Ke-Jin Huang, Le Wang, Hai-Yan Cheng, Department of Gynaecology Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Author contributions: Cheng HY created the initial concept and study design; Wang LN and Huang KJ were responsible for data collection and verification of the raw data; Wang LN and Wang L did statistical analyses; Cheng HY, Huang KJ, and Wang LN interpreted the data; Cheng HY, Huang KJ, Wang LN, and Wang L were involved in writing the manuscript and the decision to submit for publication;all authors read and approved the final manuscript.
Institutional review board statement: All procedures in this study were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Yan Cheng, MD, Doctor, Department of Gynaecology Oncology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China. chenghaiyan1900@126.com
Received: November 5, 2021
Peer-review started: November 5, 2021
First decision: January 11, 2022
Revised: January 26, 2022
Accepted: February 15, 2022
Article in press: February 15, 2022
Published online: March 26, 2022
Processing time: 137 Days and 4.6 Hours
Core Tip

Core Tip: Cervical cancer is the most common malignant tumor in women. At present, the exact molecular mechanism of its occurrence and development mainly focuses on the regulation of gene expression level, while few researches on the regulation of protein level of translation products. Ubiquilin4 (UBQLN4) regulates protein homeostasis in cells through interactions with different products and proteasomal degradation. Studies have found that the expression of UBQLN4 was associated with several tumors. However, the association between UBQLN4 and cervical cancer has not been examined. In this study, we aimed to measure association between UBQLN4 expression and poor prognosis in cervical cancer.