Liang HX, Yang YL, Zhang Q, Xie Z, Liu ET, Wang SX. Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report . World J Clin Cases 2022; 10(4): 1423-1431 [PMID: 35211579 DOI: 10.12998/wjcc.v10.i4.1423]
Corresponding Author of This Article
En-Tao Liu, MD, Doctor, WeiLun PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Room 526, 5/F, Weilun Building of Guangdong Provincial People's Hospital, No. 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. liuentao@gdph.org.cn
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
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Liang HX, Yang YL, Zhang Q, Xie Z, Liu ET, Wang SX. Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report . World J Clin Cases 2022; 10(4): 1423-1431 [PMID: 35211579 DOI: 10.12998/wjcc.v10.i4.1423]
Han-Xiang Liang, Department of Nuclear Medicine, Maoming People's Hospital, Maoming 525000, Guangdong Province, China
Yue-Long Yang, Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Qing Zhang, En-Tao Liu, Shu-Xia Wang, WeiLun PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Zhi Xie, Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Author contributions: Liang HX and Yang YL contributed to the conception and design; Liang HX, Yang YL, and Zhang Q contributed to the interpretation of imaging; Yang YL, Zhang Q, and Xie Z contributed to the interpretation of history, treatments, and histopathology; Liang HX and Liu ET contributed to the drafting of the manuscript; Liu ET and Wang SX contributed to the revised the manuscript.
Supported byGuangdong Medical Research Fund to Han-Xiang Liang, No. B2021084; Traditional Chinese Medicine Bureau of Guangdong Province to En-Tao Liu, No. 20211005; and High-level Hospital Construction Research Project of Maoming People's Hospital to Han-Xiang Liang, No. ZX2020014.
Informed consent statement: Publication consent has been obtained from the patient in a written form.
Conflict-of-interest statement: All authors have completed the ICMJE uniform disclosure form. The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: En-Tao Liu, MD, Doctor, WeiLun PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Room 526, 5/F, Weilun Building of Guangdong Provincial People's Hospital, No. 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. liuentao@gdph.org.cn
Received: September 5, 2021 Peer-review started: September 5, 2021 First decision: October 22, 2021 Revised: November 3, 2021 Accepted: December 23, 2021 Article in press: December 23, 2021 Published online: February 6, 2022 Processing time: 141 Days and 5.8 Hours
Core Tip
Core Tip: Langerhans cell histiocytosis (LCH) is a rare hematological disease characterized by a clonal proliferation of abnormal langerhans cells. It can affect any organ or system, especially the bone, skin, lung, and central nervous system (CNS). In the CNS, the hypothalamic-pituitary is predominantly affected, whereas the brain parenchyma is rarely affected. Cases of LCH involving the brain parenchyma and presenting as an isolated brain tumour have been reported, but all the reports lack complete multimodal imaging. In this manuscript, we have reported a case of LCH involving the brain parenchyma and bilateral lungs, which was assessed using computed tomography (CT), high-resolution CT, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography/CT. Furthermore, we have reviewed the relevant literature.
