©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2022; 10(4): 1381-1387
Published online Feb 6, 2022. doi: 10.12998/wjcc.v10.i4.1381
Published online Feb 6, 2022. doi: 10.12998/wjcc.v10.i4.1381
Toxic epidermal necrolysis induced by ritodrine in pregnancy: A case report
Wen-Yu Liu, Xian-Ming Xu, Tian-Yi Ye, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
Jia-Rong Zhang, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Liu WY and Ye TY collected the patient data, contributed to conception of the manuscript, reviewed the literature, and wrote the paper; the surgery was performed by Xu XM and Zhang JR; Xu XM and Zhang JR were responsible for the revision of the manuscript for important intellectual content; all authors read and approved the final manuscript.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Tian-Yi Ye, MD, Doctor, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xinsongjiang Road, Songjiang District, Shanghai 201600, China. yty1119@sina.com
Received: September 3, 2021
Peer-review started: September 3, 2021
First decision: November 11, 2021
Revised: November 21, 2021
Accepted: December 25, 2021
Article in press: December 25, 2021
Published online: February 6, 2022
Processing time: 142 Days and 17.9 Hours
Peer-review started: September 3, 2021
First decision: November 11, 2021
Revised: November 21, 2021
Accepted: December 25, 2021
Article in press: December 25, 2021
Published online: February 6, 2022
Processing time: 142 Days and 17.9 Hours
Core Tip
Core Tip: Toxic epidermal necrolysis (TEN) is a rare life-threatening cutaneous drug reaction, which may be a threat to the mother and the fetus during pregnancy. In our case, the patient’s condition began to improve when the ritodrine was stopped. So ritodrine hydrochloride could be a cause of TEN. If a rash occurs during the use of ritodrine, it is urgent for doctors to consider the side-effect of the drug and to stop its use immediately. The use of tocolytic agents should be individualized and depend on potential adverse events and maternal condition.