©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2022; 10(35): 13129-13137
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.13129
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.13129
Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
Kuo-Shyang Jeng, Department of General Surgery, Far Eastern Memorial Hospital, New Taipei 220, Taiwan
Chun-Chieh Huang, Department of Radiology, Far Eastern Memorial Hospital, New Taipei 220, Taiwan
Chen-Shuan Chung, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei 220, Taiwan
Chiung-Fang Chang, Department of Medical Research, Far Eastern Memorial Hospital, New Taipei 220, Taiwan
Author contributions: Jeng KS and Huang CC contributed equally to this work; Jeng KS designed the study; Jeng KS, Huang CC, Chung CS conducted the study; Jeng KS, Huang CC, and Chang CF wrote and edited the manuscript; and all authors read and approved the final manuscript.
Supported by the Far Eastern Memorial Hospital , No. FEMH-2021-C-002, and No. FEMH-2022-C-122; the Ministry of Science and Technology , Taiwan, No. MOST 109-2314-B-418-007, and No. MOST 110-2314-B-418-009; and the National Health Research Institutes , No. NHRI-109BCCO-MF-202020-01, and No. NHRI-111BCCO-EB-222218 for FEMH Human Biobank.
Informed consent statement: Ethical approval for this case report was obtained from Research Ethics Review Committee, Far Eastern Memorial Hospital (APPROVAL Number: 109054-C, 109012-E). Informed consent for patient information was waived because 109054-C only included a single patient, and the 109012-E sample was from the biobank.
Conflict-of-interest statement: All the authors have no conflict to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Kuo-Shyang Jeng, MD, Professor, Department of General Surgery, Far Eastern Memorial Hospital, No. 21 Sec. 2, Nanya S. Road, Banciao District, New Taipei 220, Taiwan. kevin.ksjeng@gmail.com
Received: October 20, 2022
Peer-review started: October 20, 2022
First decision: October 28, 2022
Revised: November 8, 2022
Accepted: November 22, 2022
Article in press: November 22, 2022
Published online: December 16, 2022
Processing time: 55 Days and 0.3 Hours
Peer-review started: October 20, 2022
First decision: October 28, 2022
Revised: November 8, 2022
Accepted: November 22, 2022
Article in press: November 22, 2022
Published online: December 16, 2022
Processing time: 55 Days and 0.3 Hours
Core Tip
Core Tip: Collision tumors of the liver are not common. Coexisting hepatocellular carcinomas (HCCs) and neuroendocrine carcinomas (NECs) with collision tumor patterns are extremely uncommon. Herein, we report a case of an HCC-NEC collision tumor of the liver. Definite diagnosis is usually difficult until pathological confirmation. The prognosis is poor. Early discovery of NEC may allow better treatment strategies.