©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2022; 10(29): 10735-10741
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10735
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10735
Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report
Amer Alshengeti, Department of Pediatrics, College of Medicine, Taibah University; De
Author contributions: Alshengeti A has prepared and finalized the whole manuscript.
Informed consent statement: This case report was approved by the Research Ethics Board of King Abdullah International Medical Research Center (KAIMRC), National Guard Health Affairs (NGHA), Ministry of National Guard, Jeddah, Saudi Arabia. Written informed consent was obtained from the patient’s father.
Conflict-of-interest statement: The author declares no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Amer Alshengeti, MD, Assistant Professor, Department of Pediatrics, College of Medicine, Taibah University, Al-Qiblatain District, P.O. BOX 4495, Al-Madinah 41491, Saudi Arabia. aalshengeti@dal.ca
Received: May 27, 2022
Peer-review started: May 27, 2022
First decision: July 12, 2022
Revised: August 10, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: October 16, 2022
Processing time: 124 Days and 22.6 Hours
Peer-review started: May 27, 2022
First decision: July 12, 2022
Revised: August 10, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: October 16, 2022
Processing time: 124 Days and 22.6 Hours
Core Tip
Core Tip: Diagnosis of primary immunodeficiency syndromes is challenging, especially those involving the innate immune system. Whole-exome sequencing (WES) is a promising method for diagnosis but has limitations. This article reports a case of delayed diagnosis of Dedicator of cytokinesis 8 deficiency based on negative WES results and highlights the importance of specific gene testing, when the clinical features are suggestive of specific disease, rather than depending on WES alone.