Role of short chain fatty acids in gut health and possible therapeutic approaches in inflammatory bowel diseases

doi:10.12998/wjcc.v10.i28.9985

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World Journal of Clinical Cases

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World J Clin Cases. Oct 6, 2022; 10(28): 9985-10003
Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.9985

Role of short chain fatty acids in gut health and possible therapeutic approaches in inflammatory bowel diseases

Marcos Antônio Ferreira Caetano, Patricia Castelucci

Marcos Antônio Ferreira Caetano, Patricia Castelucci, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508900, SP, Brazil

Author contributions: Caetano MAF was responsible for the literature review, and analysis and written; Castelucci P performed the critical interpretation and revised the manuscript for intellectual content.

Supported by the Research Support Foundation of the State of São Paulo, FAPESP, Brazil, No. n2014/25927-2 and No. 2018/07862-1; and Higher Education Personnel Improvement Coordination (CAPES, Brazil), No. n88887.506345/2020-00.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Corresponding author: Patricia Castelucci, MHSc, PhD, Associate Professor, Associate Research Scientist, Lecturer, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, 2415 Av. Professor Lineu Prestes, São Paulo 05508900, SP, Brazil. pcastel@usp.br

Received: June 19, 2022
Peer-review started: June 19, 2022
First decision: July 11, 2022
Revised: August 2, 2022
Accepted: August 25, 2022
Article in press: August 25, 2022
Published online: October 6, 2022
Processing time: 99 Days and 21.1 Hours

Core Tip

Core Tip: This review addresses the main epidemiological, and pathophysiological aspects of inflammatory bowel diseases (IBDs), characterizes the intestinal microbiota, and describes, in more details, the production, metabolism, and main effects of short-chain fatty acids (SCFAs) on various aspects of intestinal health, elucidating potential therapeutic effects of SCFAs in IBDs. In addition, this review addresses aspects of the modulation of SCFA production and encourages further studies on the subject seeking clinical application.