Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2022; 10(23): 8224-8231
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8224
Sepsis complicated with secondary hemophagocytic syndrome induced by giant gouty tophi rupture: A case report
Bin Lai, Zhi-Hui Pang
Bin Lai, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Zhi-Hui Pang, Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Author contributions: Both authors were involved in the treatment and case of the patient; Lai B collected the patient’s data and wrote the initial draft of the manuscript; Pang ZH critically appraised and revised the overall content of the manuscript; All authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81774336 (to Pang ZH).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Hui Pang, MD, Chief Physician, Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 12 Airport Road, Baiyun District, Guangzhou 510405, Guangdong Province, China. adi_007@126.com
Received: June 8, 2021
Peer-review started: June 8, 2021
First decision: July 15, 2021
Revised: July 27, 2021
Accepted: July 8, 2022
Article in press: July 8, 2022
Published online: August 16, 2022
Processing time: 419 Days and 1.7 Hours
Core Tip

Core Tip: Sepsis and secondary hemophagocytic syndrome induced by gouty tophi rupture are very rare in a clinical setting. Since the early symptoms are similar to gouty arthritis, it is easy to ignore septic infection and immune system damage. Sepsis and hemophagocytic syndrome develop rapidly. Often, when detected by clinicians, patients have life-threatening symptoms. This case emphasizes that clinicians should screen patients with gouty tophi rupture for early complications of sepsis and immune system damage. It is, therefore, important to improve the relevant examination as soon as possible and initiate early intervention.